Relationship between cardiovascular health and COPD andits impact on all-cause mortality in patients with COPD: analyses of NHANES 2005-2018.

IF 2.8 3区医学 Q2 RESPIRATORY SYSTEM

BMC Pulmonary Medicine Pub Date : 2025-08-19 DOI:10.1186/s12890-025-03783-x

Kang Wang, Chunyan Li, Lijun He, Xiaolong Chen

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引用次数: 0

Abstract

Background: Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are intimately connected. A recently developed measure called Life's Essential 8 (LE8) is used to evaluate cardiovascular health (CVH). We aimed to investigate the relationship between LE8 and the prevalence of COPD, and the association between LE8 and all-cause mortality in individuals with COPD.

Methods: The National Health and Nutrition Examination Survey (NHANES) 2005-2018 was the source of the data used in our investigation. The participants were divided into three groups according to their LE8 scores: low (< 50), moderate (50-79), and high (≥ 80) CVH. Weighted logistic regression models and restricted cubic spline (RCS) curves were used to examine the relationship between LE8 score and the prevalence of COPD. To determine whether the results were stable, we used subgroup and sensitivity analyses. Furthermore, we evaluated the association between LE8 and all-cause mortality in COPD patients using a weighted Cox regression analysis.

Results: Weighted logistic regression analysis of the fully adjusted model indicated that a higher LE8 score was associated with a lower prevalence of COPD (OR = 0.75; 95% CI, 0.71-0.79). The RCS curves showed a linear negative association between them. LE8 score was negatively correlated with the prevalence of COPD across all subgroups, and this negative correlation was significant in those younger than 60 years old. The sensitivity analysis's results were consistent with the primary findings. Furthermore, weighted Cox regression analysis of the fully adjusted model showed that LE8 score was negatively associated with all-cause mortality in COPD patients (HR = 0.81, 95% CI = 0.74-0.89).

Conclusions: LE8 score was negatively associated not only with the prevalence of COPD, but also with all-cause mortality in patients with COPD.

Clinical trial number: Not applicable.

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心血管健康与COPD的关系及其对COPD患者全因死亡率的影响：NHANES 2005-2018分析

背景：慢性阻塞性肺疾病（COPD）与心血管疾病（CVD）密切相关。最近开发的一种名为生命必需8 （LE8）的测量方法被用于评估心血管健康（CVH）。我们的目的是研究LE8与COPD患病率之间的关系，以及LE8与COPD患者全因死亡率之间的关系。方法：本研究使用的数据来自2005-2018年国家健康与营养检查调查（NHANES）。根据LE8评分将参与者分为三组：低(结果：完全调整模型的加权logistic回归分析表明，LE8评分较高与COPD患病率较低相关（OR = 0.75; 95% CI, 0.71-0.79）。RCS曲线显示两者呈线性负相关。在所有亚组中，LE8评分与COPD患病率呈负相关，且这种负相关在年龄小于60岁的人群中更为显著。敏感性分析结果与初步研究结果一致。此外，全校正模型的加权Cox回归分析显示，LE8评分与COPD患者全因死亡率呈负相关（HR = 0.81, 95% CI = 0.74-0.89）。结论：LE8评分不仅与COPD患病率呈负相关，而且与COPD患者的全因死亡率呈负相关。临床试验号：不适用。

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来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.