{"title":"Epidermal Homeostasis in Space from the Stand Point of Keratinocyte Physiology.","authors":"Mitsuhiro Denda","doi":"10.1159/000547984","DOIUrl":null,"url":null,"abstract":"<p><p>The human epidermis is the interface between the human body and the environment. It is mainly comprised of keratinocytes. Since the beginning of this century, functional expression of a series of receptors for various environmental factors has been reported. Moreover, neurotransmitters and hormones originally found in the central nervous system are generated and released from keratinocytes. Thus, the pathophysiology of the epidermis is important not only for skin health but also for whole-body conditions. In outer space, humans must confront environmental factors different from those on Earth, such as electromagnetic fields, drastic changes in atmospheric pressure or humidity, and microgravity. In this review, the author discusses the potential effects of these factors on epidermal homeostasis and whole-body conditions.</p>","PeriodicalId":21748,"journal":{"name":"Skin Pharmacology and Physiology","volume":" ","pages":"1-11"},"PeriodicalIF":3.2000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Skin Pharmacology and Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000547984","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The human epidermis is the interface between the human body and the environment. It is mainly comprised of keratinocytes. Since the beginning of this century, functional expression of a series of receptors for various environmental factors has been reported. Moreover, neurotransmitters and hormones originally found in the central nervous system are generated and released from keratinocytes. Thus, the pathophysiology of the epidermis is important not only for skin health but also for whole-body conditions. In outer space, humans must confront environmental factors different from those on Earth, such as electromagnetic fields, drastic changes in atmospheric pressure or humidity, and microgravity. In this review, the author discusses the potential effects of these factors on epidermal homeostasis and whole-body conditions.
期刊介绍：
In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.
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