Relationship Between Serum Autotaxin Levels and Fasting Bile Acid in Intrahepatic Cholestasis of Pregnancy

IF 2.4 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2025-08-18 DOI:10.1111/aji.70142

Zuhal Köksal, Tuğba Ağbal, Funda Güçel, Şeyma Sarışen

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引用次数: 0

Abstract

Objective

Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disease, especially in the second and third trimesters of pregnancy. Autotaxin (ATX) has been reported to play a critical role, especially in cholestatic pruritus, and serum ATX levels are associated with ICP. The aim of this study was to determine the serum ATX level in ICP, to evaluate its relationship with fasting bile acid (FBA) level, and its use in the diagnosis of ICP.

Methods

Forty-three patients diagnosed with ICP and 45 healthy pregnant women were included in the study. Gestational week at diagnosis, serum parameters, FBA, pruritus intensity, gestational week, and birth weight were recorded. Venous blood was collected from all patients for ATX levels, stored under appropriate conditions, and measured enzymatically after the study was completed.

Results

Although ATX level was found to be higher in patients with ICP (n = 43; 350.5 ± 348.7 pg/mL) compared to the control group (n = 45; 219.7 ± 131.5 pg/mL), this increase was not statistically significant (p = 0.325). Again, no significant correlation was found between ATX levels and FBA levels (p = 0.326). There was a weak correlation between the severity of pruritus and serum FBA levels (p = 0.024), but no correlation was found between ATX levels and pruritus severity (p = 0.437).

Conclusion

There was no significant difference in autotoxin levels in pregnant women with ICP compared to healthy pregnant women. These findings suggest that autotoxin activity may not be appropriate for the diagnosis of ICP, and larger clinical studies are needed to understand the effect of autotoxin in ICP.

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妊娠肝内胆汁淤积症患者血清自taxin水平与空腹胆汁酸的关系

目的妊娠肝内胆汁淤积症（ICP）是最常见的妊娠相关肝脏疾病，尤其是在妊娠中期和晚期。Autotaxin （ATX）已被报道起关键作用，特别是在胆汁淤积性瘙痒中，血清ATX水平与ICP相关。本研究的目的是测定ICP患者血清ATX水平，评估其与空腹胆汁酸（FBA）水平的关系，及其在ICP诊断中的应用。方法选择43例ICP患者和45例健康孕妇为研究对象。记录诊断时的妊娠周、血清参数、FBA、瘙痒强度、妊娠周和出生体重。收集所有患者静脉血检测ATX水平，保存在适当的条件下，并在研究结束后进行酶学测定。结果虽然发现ICP患者的ATX水平较高(n = 43；350.5±348.7 pg/mL)，与对照组(n = 45；219.7±131.5 pg/mL)，差异无统计学意义（p = 0.325）。同样，ATX水平与FBA水平无显著相关性（p = 0.326）。瘙痒严重程度与血清FBA水平呈弱相关（p = 0.024），而ATX水平与瘙痒严重程度无相关性（p = 0.437）。结论ICP孕妇自身毒素水平与健康孕妇无显著差异。这些发现提示，自体毒素活性可能不适合用于ICP的诊断，需要更大规模的临床研究来了解自体毒素在ICP中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.