Primary bone lymphoma: A rare case of mandibular diffuse large B-cell lymphoma in a background of osteomyelitis.

IF 2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-08-12 DOI:10.1016/j.jormas.2025.102521

Océane Mériaux, Eric Lagrue, Marion Morcel, Chloé Antier, Philippe Lesclous

引用次数: 0

Abstract

Primary bone lymphoma is a rare and extra nodal type of non-Hodgkin lymphoma. It accounts for less than 1% of all lymphomas. It can affect various bones, most commonly the femur or humerus. However, it rarely affects the jawbone, especially the mandible. Diffuse large B-cell lymphoma is a subtype of non-Hodgkin lymphoma. This case report describes a 59-year-old woman who presented with worsening swelling of the symphyseal region of the mandible. Initially, she was diagnosed for an acute osteomyelitis in the context of previous periodontitis and treated accordingly. However, the patient did not respond to two courses of amoxicillin therapy. Ultimately, a biopsy revealed diffuse large B-cell lymphoma. The cases's strength lies in its potential to establish a link between local inflammatory disease and the onset of a DBCL. Furthermore, long-term clinical and imaging follow-up has demonstrated a favorable prognosis with standard chemotherapy.

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原发性骨淋巴瘤：一例罕见的下颌弥漫性大b细胞淋巴瘤并发骨髓炎。

原发性骨淋巴瘤是一种罕见的淋巴结外型非霍奇金淋巴瘤。它占所有淋巴瘤的不到1%。它可以影响各种骨骼，最常见的是股骨或肱骨。然而，它很少影响颌骨，尤其是下颌骨。弥漫性大b细胞淋巴瘤是非霍奇金淋巴瘤的一种亚型。这个病例报告描述了一个59岁的妇女谁提出恶化肿胀的下颌骨的联合区。最初，她被诊断为急性骨髓炎的背景下，以前的牙周炎和治疗。然而，患者对两个疗程的阿莫西林治疗没有反应。最终，活检显示弥漫性大b细胞淋巴瘤。这些病例的优势在于它有可能建立局部炎症性疾病与大DBCL发病之间的联系。此外，长期的临床和影像学随访显示标准化疗的预后良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.