One-Pot Tandem Alkylsulfonylation/Cyclization of Unactivated Alkenes to Construct Alkylsulfonyl-Containing Polycyclic Quinazolinones Under Photocatalysis

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-06-13 DOI:10.1002/ajoc.202500341

Rong Huang, Prof. Zhen Yao, Jing Guan, Bowen Pan, Yang Shi, Huabin Wang, Xiongwei Liu, Prof. Ying Zhou, Lijin Xu

引用次数: 0

Abstract

Visible-light photoredox-catalyzed one-pot tandem alkylsulfonylation/cyclization of unactivated alkenes to construct alkylsulfonyl-containing polycyclic quinazolinones from 4-alkyl Hantzsch esters, DABCO(SO₂)₂ and N-alkene-tethered quinazolinones has been accomplished. This mild transformation accommodates diversely decorated substrates, affords the target products in 69–90% yields, and can be readily scaled up. The efficacy of the current catalysis arises from the use of tetrabutylammonium decatungstate as the photocatalyst and cheap K₂S₂O₈ as the oxidant.

Abstract Image

查看原文本刊更多论文

光催化下非活化烯烃单锅串联烷基磺酰化/环化制备含烷基磺酰多环喹唑啉酮

以4-烷基Hantzsch酯、DABCO(SO2)2和n -烯系喹唑啉酮为原料，在可见光催化下进行了一锅串联烷基磺酰化/环化反应，合成了含烷基磺酰的多环喹唑啉酮。这种温和的转变适应不同装饰的基材，提供69-90%的产量目标产品，并且可以很容易地扩大规模。采用廉价的K2S2O8作为氧化剂，以十钨酸四丁基铵为光催化剂，提高了催化效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.