Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration

IF 4.6 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2025-07-07 DOI:10.1016/j.xops.2025.100881

Swetha Bindu Velaga MS , Ahmed Roshdy Alagorie MD , Muneeswar Gupta Nittala MPhil , Noel C. Moore PhD , Yeunjoo E. Song PhD , Jonathan Haines PhD , Margaret A. Pericak-Vance PhD , Dwight Stambolian MD , Zhihong Hu PhD , Ye He MD, PhD , Srinivas R. Sadda MD

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Abstract

Purpose

To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD).

Design

Longitudinal cohort study.

Subjects

The study reviewed 1332 eyes from 666 subjects with baseline and 2-year follow-up data, of which 108 eyes were graded to have RPD. Among these, 35 eyes from 22 participants (mean age: 72.8 ± 8.9 years; range: 50–84; 37% female) were eligible for this analysis because they had early or intermediate AMD with RPD at baseline, absence of geographic atrophy at 2 years, and images that were gradable for the presence of RPD.

Methods

Infrared reflectance (IR), blue-light fundus autofluorescence, and spectral-domain OCT were obtained for all subjects at baseline and at 2 years. Using the instrument software, a certified grader delineated the RPD area (mm²) on the IR image using the free hand tool. Choroidal thickness was measured for both baseline and month 24 using a previously described deep learning algorithm to compute a choroidal volume.

Main Outcome Measures

Changes in RPD area (mm²) and mean volumetric choroidal thickness (μm) between baseline and 2 years.

Results

The RPD area increased significantly (P < 0.001) by month 24 compared with baseline with a mean increase of 6.23 ± 4.64 mm². The mean volumetric choroidal thickness was not significantly different from baseline 182.2 ± 94.36 (134.20–227.90) to month 24 178.2 ± 41.10 (109–258).

Conclusions

In this longitudinal natural history analysis, we observed an increase in RPD area of >6 mm² over 2 years in the absence of a significant change in choroidal thickness. Although AMD eyes with presence of RPD typically have a thinner choroid, the increase in extent of these lesions does not appear to be associated with further thinning of the choroid.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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老年性黄斑变性眼网状假性视网膜面积的纵向评价

目的探讨老年性黄斑变性（AMD）患者2年内网状假性黄斑（RPD）面积及脉络膜厚度的变化。设计纵向队列研究。该研究回顾了来自666名受试者的1332只眼睛的基线和2年随访数据，其中108只眼睛被分级为RPD。其中，22名参与者35只眼睛(平均年龄：72.8±8.9岁；范围:50 - 84;37%的女性)有资格进行这项分析，因为他们在基线时患有早期或中期AMD并RPD， 2年后没有地理萎缩，并且图像可分级是否存在RPD。方法对所有受试者进行基线和2年时的红外反射率（IR）、蓝光眼底自身荧光和光谱域OCT检测。使用仪器软件，一个经过认证的分级员使用徒手工具在红外图像上划定RPD区域（mm2）。使用先前描述的深度学习算法来计算脉络膜体积，测量基线和第24个月的脉络膜厚度。主要观察指标：基线和2年间RPD面积（mm2）和平均脉络膜厚度（μm）的变化。结果RPD面积明显增大(P <；0.001)，与基线相比，第24个月平均增加6.23±4.64 mm2。平均脉络膜体积厚度从基线182.2±94.36（134.20-227.90）到24月178.2±41.10（109-258）无显著差异。在这项纵向自然史分析中，我们观察到在脉络膜厚度没有明显变化的情况下，RPD面积在2年内增加了6mm2。虽然伴有RPD的AMD眼睛通常有较薄的脉络膜，但这些病变范围的增加似乎与脉络膜的进一步变薄无关。财务披露专有或商业披露可在本文末尾的脚注和披露中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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