Regulation of transforming growth factor beta 1 in the ovary of ovoviviparous black rockfish (Sebastes schlegelii)

IF 1.7 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

General and comparative endocrinology Pub Date : 2025-08-10 DOI:10.1016/j.ygcen.2025.114799

Xiao Jing, Likang Lyu, Chenpeng Zuo, Jianshuang Li, Xiaojie Wang, Jing Yang, Tianyu Jiang, Yun Li, Haishen Wen, Xin Qi

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Abstract

Transforming growth factor beta 1 (TGF-β1), a multifunctional secreted polypeptide cytokine, has been reported to play crucial roles in pregnancy process of mammals, including immune tolerance and embryonic development. However, less is known in Pisces. Aimed to figure out the molecular mechanism underlying TGF-β1 functions, black rockfish (Sebastes schlegelii), an ovoviviparity teleost, which process the sperm storage and gestation periods, was employed as the research model. In the present study, we found that tgfb1 among four tgfb isoforms was highly expressed and localized in ovary. The recombinant TGF-β1 (rTGF-β1) was mainly involved in immune response, signal transduction, angiogenesis and cell death by analyzing transcriptome of ovarian cells. The current results reveal the pivotal role of TGF-β1 in black rockfish ovary and provide novel insights into cytokines in the pregnancy of ovoviviparity teleost.

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卵胎生黑岩鱼卵巢转化生长因子β 1的调控

转化生长因子β1 （TGF-β1）是一种多功能分泌型多肽细胞因子，据报道在哺乳动物妊娠过程中，包括免疫耐受和胚胎发育中起着至关重要的作用。然而，对双鱼座的了解却很少。为了弄清TGF-β1功能的分子机制，我们以卵生硬骨鱼黑岩鱼（sebases schlegelii）作为研究模型，黑岩鱼是一种处理精子储存和妊娠期的硬骨鱼。在本研究中，我们发现tgfb四种亚型中tgfb1在卵巢中高度表达和定位。重组TGF-β1 （rTGF-β1）主要参与卵巢细胞的免疫应答、信号转导、血管生成和细胞死亡。本研究结果揭示了TGF-β1在黑岩鱼卵巢中的关键作用，并为细胞因子在卵生硬骨鱼妊娠中的作用提供了新的见解。

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来源期刊

General and comparative endocrinology 医学-内分泌学与代谢

CiteScore

5.60

自引率

7.40%

发文量

120

审稿时长

2 months

期刊介绍： General and Comparative Endocrinology publishes articles concerned with the many complexities of vertebrate and invertebrate endocrine systems at the sub-molecular, molecular, cellular and organismal levels of analysis.