Effects of fasting and training on pyruvate dehydrogenase activation during exercise.

J T Brozinick, V K Patel, G L Dohm
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引用次数: 8

Abstract

1. The effect of exercise (2 hr treadmill running at 28 m/min) on PDHa (the activity of the active form of pyruvate dehydrogenase) in untrained rats, trained rats (2 hr/d at 25 m/min for 4 wk), and in 24 hr fasted rats was determined. 2. Exercise increased PDHa activity approximately 2 fold in fed-untrained rats. 3. Fasting decreased PDHa activity in sedentary rats to approximately half the activity in fed rats. 4. The increase in PDHa activity during exercise was less in fasted than fed rats. 5. Training did not change the total activity of PDH (phosphorylated plus nonphosphorylated forms) but the percent of PDH in the active form was increased in muscle of trained-rested rats. 6. PDHa activity was unchanged by acute exercise (2.5 hr at 40 m/min) in the trained rats.

禁食和训练对运动中丙酮酸脱氢酶激活的影响。
1. 测定了运动(以28米/分钟的速度在跑步机上跑2小时)对未训练大鼠、训练大鼠(以25米/分钟的速度每天跑2小时,持续4周)和禁食24小时大鼠PDHa(丙酮酸脱氢酶活性形式的活性)的影响。2. 运动使未经训练的大鼠的PDHa活性增加了约2倍。3.禁食使久坐大鼠的PDHa活性下降到喂食大鼠的一半左右。4. 禁食大鼠运动时PDHa活性的增加比喂食大鼠少。5. 训练没有改变PDH的总活性(磷酸化和非磷酸化形式),但在训练休息的大鼠肌肉中,活性形式的PDH的百分比增加了。6. 在训练大鼠中,PDHa活性在急性运动(以40米/分钟速度2.5小时)中没有变化。
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