Clock genes tune plasticity of group 3 innate lymphoid cells

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-08-13 DOI:10.1038/s41590-025-02245-0

Siu Ling Tai, Louis Ngai, Arthur Mortha

引用次数: 0

Abstract

Circadian oscillation of gene expression controls gut tissue homeostasis. The transcription factors REV-ERBα and REV-ERBβ, which control the expression of clock genes, are also central to maintaining innate lymphoid cells in a state that facilitates the maintenance of a balanced and healthy intestine.

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时钟基因调节第3组先天淋巴样细胞的可塑性

基因表达的昼夜振荡控制着肠道组织的稳态。转录因子rev - erba和rev - erbb β控制生物钟基因的表达，对于维持先天淋巴样细胞处于促进肠道平衡和健康的状态也至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.