Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, Jose M Adrover
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引用次数: 0
Abstract
Cancer and cardiovascular disease together are leading causes of death worldwide, and cancer patients display an abnormally elevated burden of cardiovascular disease. Neutrophils-key immune cells known primarily by their roles in inflammation and infection-can link these two pathological conditions. Neutrophils contribute to cancer progression and cardiovascular complications through various mechanisms, including their ability to promote inflammation, thrombosis, and vascular damage by interacting with vascular endothelial cells, platelets, and other immune cells, or by forming NETs. In cancer, neutrophils contribute to a hypercoagulability state, which promotes tumor growth and metastasis, and can also lead to thrombotic events, myocardial infarction, and stroke. Cancer affects neutrophil numbers and functional properties, induces the appearance of several neutrophil subtypes, and can alter hematopoiesis. Here we summarize the links between cancer and cardiovascular disease, focusing on the role of neutrophils and cancer-elicited changes to their function in connecting these two disease states and highlighting the neutrophils' dynamic interaction with both diseases.
期刊介绍：
Since its establishment in 1896, the Journal of Experimental Medicine (JEM) has steadfastly pursued the publication of enduring and exceptional studies in medical biology. In an era where numerous publishing groups are introducing specialized journals, we recognize the importance of offering a distinguished platform for studies that seamlessly integrate various disciplines within the pathogenesis field.
Our unique editorial system, driven by a commitment to exceptional author service, involves two collaborative groups of editors: professional editors with robust scientific backgrounds and full-time practicing scientists. Each paper undergoes evaluation by at least one editor from both groups before external review. Weekly editorial meetings facilitate comprehensive discussions on papers, incorporating external referee comments, and ensure swift decisions without unnecessary demands for extensive revisions.
Encompassing human studies and diverse in vivo experimental models of human disease, our focus within medical biology spans genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We eagerly welcome reports ranging from atomic-level analyses to clinical interventions that unveil new mechanistic insights.
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