Yousra Sbibih, Abderrazak Saddari, Ilham Alla, Said Ezrari, Elmostapha Benaissa, Yassine Ben Lahlou, Mostafa Elouennass, Adil Maleb
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引用次数: 0
Abstract
Background and objectives: Helicobacter pylori, identified in 1982, remains a major cause of gastric infections. Despite extensive research, an ideal treatment regimen for its eradication is yet to be determined, with antibiotic resistance posing a significant challenge. This study, conducted at Mohammed VI University Hospital, aimed to evaluate and compare the effectiveness of different therapeutic protocols for H. pylori eradication.
Materials and methods: This 13-month retrospective descriptive study was conducted at the Microbiology Laboratory of Mohammed VI University Hospital in Oujda, Morocco, to evaluate patients suspected of H. pylori infection using the urea breath test.
Results: A total of 190 patients were included, with an overall eradication rate of 73%. Three therapeutic protocols were tested, and bismuth concomitant therapy showed the highest eradication rate at 82%, outperforming the other regimens.
Conclusion: These findings highlight the importance of combining antimicrobial agents with antisecretory treatments to enhance eradication outcomes. The study also emphasizes the need for novel treatment strategies, particularly in light of rising antibiotic resistance. Vonoprazan-based regimens appear to offer a promising alternative, especially in the absence of antibiotic sensitivity testing. Future research should focus on optimizing treatment protocols while preserving beneficial gut flora.
背景和目的：幽门螺杆菌于1982年被发现，是胃感染的主要原因。尽管进行了广泛的研究，但根除该病的理想治疗方案尚未确定，抗生素耐药性构成了重大挑战。这项研究由穆罕默德六世大学医院进行，旨在评估和比较不同治疗方案根除幽门螺杆菌的有效性。材料和方法：这项为期13个月的回顾性描述性研究是在摩洛哥Oujda Mohammed VI大学医院微生物实验室进行的，目的是用尿素呼气试验评估疑似幽门螺杆菌感染的患者。结果：共纳入190例患者，总根除率为73%。测试了三种治疗方案，铋伴随治疗的根除率最高，达到82%，优于其他方案。结论：这些发现强调了抗菌药物联合抗分泌治疗对提高根除效果的重要性。该研究还强调需要新的治疗策略，特别是考虑到抗生素耐药性的上升。以vonoprazan为基础的治疗方案似乎提供了一个有希望的替代方案，特别是在缺乏抗生素敏感性测试的情况下。未来的研究应侧重于优化治疗方案，同时保留有益的肠道菌群。
期刊介绍：
The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.
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