Intraocular Pressure After Anti-Vascular Endothelial Growth Factor Injection in Eyes With a Mineralized Bruch's Membrane Caused by Pseudoxanthoma Elasticum.

IF 4.7 2区医学 Q1 OPHTHALMOLOGY

Investigative ophthalmology & visual science Pub Date : 2025-08-01 DOI:10.1167/iovs.66.11.25

Kristin Raming, Isabel Saltenberger, Jonathan Meinke, Sara Risseeuw, Karl Mercieca, Philipp Herrmann, Petrus Chang, Thomas Ach, Redmer van Leeuwen, Jeannette Ossewaarde-van Norel, Maximilian Pfau, Frank G Holz, Kristina Pfau

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引用次数: 0

Abstract

Purpose: To assess acute IOP changes after anti-VEGF injections in patients with Pseudoxanthoma elasticum (PXE) compared to other retinal diseases.

Methods: Twenty eyes of patients with PXE (mean age 63.4 ± 6.4 years) and 30 control eyes (mean age 64.8 ± 11.8 years) were included. IOP was measured prior and one, five, and 15 minutes after intravitreal injection of 50 µL anti-VEGF agent. The post-injection IOP curve was modeled by an exponential decay function, and the resulting exponential time constant (tau) served as the outcome variable in the multivariable models.

Results: IOP raised markedly after anti-VEGF injection in both groups, without significant difference in PXE compared to controls. The median tau in the PXE group was 8.6 minutes (interquartile range [IQR] = 8.2-9.4) versus 7.6 minutes (IQR = 6.8-8.9) in the control group (P = 0.02). Seven PXE patients and one control patient reported a previous transient vision loss after anti-VEGF injection. Univariate analysis showed that the diagnosis of PXE (1.12, P = 0.006), angioid streak length (0.12, P = 0.01), prior transient vision loss (1.77, P = 0.001), peripheral artery disease (0.96, P = 0.04) and the number of previous anti-VEGF injections (0.02, P = 0.014) were significantly associated with higher tau values.

Conclusions: The time to restore to baseline IOP after anti-VEGF injection is longer in PXE patients. Given the early need for anti-VEGF treatment, frequent injections, and the possible heightened vulnerability (e.g., optic disc drusen) in PXE patients, clinical trials on pre-injection IOP-lowering measures warrant consideration.

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抗血管内皮生长因子注射对弹性假黄色瘤所致矿化Bruch膜眼的眼压影响。

目的：与其他视网膜疾病相比，评估弹性假黄瘤（PXE）患者注射抗vegf后的急性IOP变化。方法：选取20只PXE患者眼（平均年龄63.4±6.4岁）和30只对照眼（平均年龄64.8±11.8岁）。在玻璃体内注射50µL抗vegf药物1、5和15分钟后测量眼压。注射后IOP曲线采用指数衰减函数建模，得到的指数时间常数（tau）作为多变量模型的结果变量。结果：两组抗vegf注射后IOP均明显升高，PXE与对照组比较无显著差异。PXE组的中位tau为8.6分钟（四分位间距[IQR] = 8.2-9.4），对照组为7.6分钟（IQR = 6.8-8.9）（P = 0.02）。7名PXE患者和1名对照患者在抗vegf注射后报告了先前的短暂性视力丧失。单因素分析显示，PXE诊断（1.12,P = 0.006）、血管样条纹长度（0.12,P = 0.01）、既往短暂性视力丧失（1.77,P = 0.001）、外周动脉疾病（0.96,P = 0.04）和既往抗vegf注射次数（0.02,P = 0.014）与tau值升高有显著相关性。结论：PXE患者注射抗vegf后IOP恢复到基线所需时间更长。考虑到PXE患者早期需要抗vegf治疗、频繁注射以及可能增加的易感性（如视盘萎缩），注射前降低眼压措施的临床试验值得考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative ophthalmology & visual science 医学-眼科学

CiteScore

6.90

自引率

4.50%

发文量

339

审稿时长

1 months

期刊介绍： Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.