Diastereoselective construction of structurally diverse polycyclic spiroindolenines via Yb(OTf)3-catalyzed cascade [1,5]-hydride transfer/cyclization

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-08-05 DOI:10.1039/d5ob01005e

Song Hu , Dan Hu , Jianming Xu , Jian Wang , Heng Yin , Ying Xie , Yulong Li , Chenyi Li

引用次数: 0

Abstract

A Lewis-acid-catalyzed redox neutral cascade [1,5]-hydride transfer/cyclization between indolin-2-imines and 2-amino-substituted benzaldehydes has been disclosed. A series of novel, pharmaceutically interesting polycyclic spiroindolenines containing tetrahydroquinolines was obtained in good to excellent yields with excellent diastereoselectivity.

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通过Yb(OTf)3催化级联[1,5]-氢化物转移/环化构建结构多样的多环螺吲哚胺。

一种lewis酸催化的氧化还原中性级联反应[1,5]-吲哚-2-亚胺和2-氨基取代苯甲醛之间的氢化物转移/环化反应已经公开。以优异的非对映选择性和良好的产率制备了一系列新颖的、药学上有趣的含四氢喹啉的多环螺吲哚啉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.