The bidirectional association between incidence of depression and obesity in Brazilian graduates (CUME study): a 6-year prospective study.

IF 3.3 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

International Journal of Food Sciences and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI:10.1080/09637486.2025.2543252

Arieta Carla Gualandi Leal, Josefina Bressan, Leidjaira Juvanhol Lopes, Adriano Marçal Pimenta, Helen Hermana Miranda Hermsdorff

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Abstract

To evaluate the bidirectional relationship between the incidence of depression and obesity in Brazilian graduates. This 6-year longitudinal follow-up study included 3,426 participants from the CUME study in assessing the incidence of obesity and 3,414 participants in assessing the incidence of depression. Risk ratios were estimated and the interaction by sex was tested using the multiplicative method. After an average follow-up of 2.13 years, 387 incident cases of depression and 216 cases of obesity were identified. When stratified by sex, women with an initial diagnosis of depression were at increased risk of developing obesity over time (HR: 2.14; 95% CI: 1.47 - 3.11). The association between initial obesity and incidence of depression was also positive, but only for men (HR: 1.82; 95% CI 1.05 - 3.16). As conclusion, there is bidirectional association for incidence of depression and obesity over time and the risks of developing these diseases are associated differently by sex.

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巴西大学毕业生抑郁和肥胖发生率的双向关联（CUME研究）：一项为期6年的前瞻性研究。

目的：探讨巴西大学毕业生抑郁与肥胖的双向关系。这项为期6年的纵向随访研究包括来自CUME研究的3,426名参与者，评估肥胖发病率，3,414名参与者评估抑郁发病率。估计风险比，并使用乘法法检验性别间的相互作用。经过平均2.13年的随访，确定了387例抑郁症和216例肥胖症。当按性别分层时，最初诊断为抑郁症的女性随着时间的推移患肥胖症的风险增加(HR: 2.14；95% ci: 1.47 - 3.11)。初始肥胖与抑郁症发病率之间也存在正相关，但仅适用于男性(HR: 1.82；95% ci 1.05 - 3.16)。综上所述，随着时间的推移，抑郁和肥胖的发病率存在双向关联，而患这些疾病的风险因性别而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Food Sciences and Nutrition 工程技术-食品科技

CiteScore

7.50

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.