Resveratrol enhances duck cathelicidin expression in heterophilic granulocytes via MAPK-EGR1 signalling pathway.

IF 1.7 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

British Poultry Science Pub Date : 2025-08-08 DOI:10.1080/00071668.2025.2541361

W Shenao, Y Hao, S Jing, C XueHong, S Xue, Q Xueyan, Z Tingting, F XingJun, L Xiao

引用次数: 0

Abstract

1. This study investigated whether resveratrol (RES) can regulate the expression of duck cathelicidins (dCATHs) in heterophilic granulocytes (HGs). To address this, HG was isolated from ducks and treated with RES, followed by transcriptome sequencing to explore potential regulatory pathways.2. Ducks receiving RES treatment had significantly increased dCATH expression in HG. Transcriptomic analysis suggested that this was associated with anti-inflammatory responses and activation of the mitogen-activated protein kinase (MAPK) signalling pathway.3. The results indicated that RES upregulates dCATH expression, potentially through MAPK pathway activation, which would contribute to enhanced immune function in ducks.

查看原文本刊更多论文

白藜芦醇通过MAPK-EGR1信号通路增强鸭cathelicidin在异亲性粒细胞中的表达。

1. 本研究探讨了白藜芦醇（resveratrol， RES）是否能调节鸭cathelicidins （dCATHs）在嗜异性粒细胞（HGs）中的表达。为了解决这个问题，我们从鸭子中分离出HG，用RES处理，然后进行转录组测序以探索潜在的调控途径。接受RES治疗的鸭子在HG中的dCATH表达显著增加，转录组学分析表明，这与抗炎反应和丝裂原活化蛋白激酶（MAPK）信号通路的激活有关。结果表明，RES可能通过激活MAPK通路上调dCATH的表达，从而增强鸭的免疫功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

British Poultry Science 农林科学-奶制品与动物科学

CiteScore

3.90

自引率

5.00%

发文量

审稿时长

4.5 months

期刊介绍： From its first volume in 1960, British Poultry Science has been a leading international journal for poultry scientists and advisers to the poultry industry throughout the world. Over 60% of the independently refereed papers published originate outside the UK. Most typically they report the results of biological studies with an experimental approach which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: anatomy, embryology, biochemistry, biophysics, physiology, reproduction and genetics, behaviour, microbiology, endocrinology, nutrition, environmental science, food science, feeding stuffs and feeding, management and housing welfare, breeding, hatching, poultry meat and egg yields and quality.Papers that adopt a modelling approach or describe the scientific background to new equipment or apparatus directly relevant to the industry are also published. The journal also features rapid publication of Short Communications. Summaries of papers presented at the Spring Meeting of the UK Branch of the WPSA are published in British Poultry Abstracts .