{"title":"Organoids and Organoids-on-Chip in Traditional Chinese Medicine Research: Applications, Advantages, and Future Prospects","authors":"Tao Li, Yifan Yang, Fengrui Yang, Yuan Li, Haifa Qiao, Yongmei Yan, Xia Ding","doi":"10.1002/cbin.70067","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Modernizing traditional Chinese medicine (TCM) requires preserving its foundational principles while integrating contemporary innovations and clarifying therapeutic methods. Organoids and organoids-on-chip technologies offer advanced models of human organs, and serve as an excellent platform for investigating TCM theories and complex herbal formulas. To systematically summarize recent progress in using organoids and organoids-on-chip in TCM research, and critically assess their technical advantages and future potential, relevant articles and information were sourced from scientific databases such as PubMed, SpringerLink, Web of Science, ScienceDirect, and VIP. The application of organoids and organoids-on-chip technologies in TCM research encompasses theory interpretation, efficacy evaluation, mechanism elucidation, toxicity assessment, active ingredient screening, and formula optimization. These applications offer significant advantages, such as unveiling holistic effects, deciphering mechanistic bases through dynamic visualization approaches, and demonstrating personalized therapeutic benefits. Enhancing physiological relevance, automation, and intelligent applications are future development directions. Organoids and organoids-on-chip represent transformative tools for the modernization of TCM. Future advancements in vascularization, neural network development, and the integration of artificial intelligence are anticipated to address existing limitations, thereby enhancing physiological relevance and clinical translation. These advancements are expected to promote global acceptance and innovation in TCM.</p>\n </div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"49 10","pages":"1233-1244"},"PeriodicalIF":3.1000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biology International","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbin.70067","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Modernizing traditional Chinese medicine (TCM) requires preserving its foundational principles while integrating contemporary innovations and clarifying therapeutic methods. Organoids and organoids-on-chip technologies offer advanced models of human organs, and serve as an excellent platform for investigating TCM theories and complex herbal formulas. To systematically summarize recent progress in using organoids and organoids-on-chip in TCM research, and critically assess their technical advantages and future potential, relevant articles and information were sourced from scientific databases such as PubMed, SpringerLink, Web of Science, ScienceDirect, and VIP. The application of organoids and organoids-on-chip technologies in TCM research encompasses theory interpretation, efficacy evaluation, mechanism elucidation, toxicity assessment, active ingredient screening, and formula optimization. These applications offer significant advantages, such as unveiling holistic effects, deciphering mechanistic bases through dynamic visualization approaches, and demonstrating personalized therapeutic benefits. Enhancing physiological relevance, automation, and intelligent applications are future development directions. Organoids and organoids-on-chip represent transformative tools for the modernization of TCM. Future advancements in vascularization, neural network development, and the integration of artificial intelligence are anticipated to address existing limitations, thereby enhancing physiological relevance and clinical translation. These advancements are expected to promote global acceptance and innovation in TCM.
中医现代化需要保留其基本原则，同时结合当代创新和澄清治疗方法。类器官和类器官芯片技术提供了先进的人体器官模型，并为研究中医理论和复杂的草药配方提供了良好的平台。为了系统总结类器官和芯片类器官在中药研究中的最新进展，并批判性地评估其技术优势和未来潜力，相关文章和信息来源于PubMed、SpringerLink、Web of Science、ScienceDirect和VIP等科学数据库。类器官和类器官芯片技术在中药研究中的应用包括理论解释、疗效评价、机制阐明、毒性评价、活性成分筛选、配方优化等。这些应用程序提供了显著的优势，例如揭示整体效果，通过动态可视化方法破译机制基础，并展示个性化治疗的益处。增强生理相关性、自动化和智能化应用是未来的发展方向。类器官和芯片类器官是中医现代化的变革性工具。未来在血管化、神经网络发展和人工智能集成方面的进展有望解决现有的局限性，从而增强生理相关性和临床翻译。这些进步有望促进全球对中医药的接受和创新。
期刊介绍：
Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect.
These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
