Rethinking relief: Targeting sensory neurons to combat cancer and pain

IF 44.5 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-08-07 DOI:10.1016/j.ccell.2025.07.019

Brian M. Davis, Lisa A. McIlvried, Jami L. Saloman, Marci L. Nilsen, Nicole N. Scheff

引用次数: 0

Abstract

Cancer pain is a complex problem that, when left unaddressed, can impact overall survival and decrease patients’ quality of life. Collaboration among medical oncologists, immunologists, and neurobiologists in the cancer neuroscience field has recently revealed a pivotal role for the sensory nervous system in cancer progression. We highlight recent scientific findings suggesting that selection of appropriate analgesics should consider not only their efficacy in reducing pain but also their potential to influence anti-tumor immunity and subsequent responses to immunotherapy.

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重新思考缓解：以感觉神经元为目标对抗癌症和疼痛

癌症疼痛是一个复杂的问题，如果不加以解决，可能会影响总体生存并降低患者的生活质量。医学肿瘤学家、免疫学家和神经生物学家在癌症神经科学领域的合作最近揭示了感觉神经系统在癌症进展中的关键作用。我们强调最近的科学发现表明，选择合适的镇痛药不仅要考虑其减轻疼痛的功效，还要考虑其影响抗肿瘤免疫和随后对免疫治疗的反应的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.