Adverse Lipid Profiles and Increased Cardiovascular Risks in People with HAM/TSP.

IF 1.1 4区医学 Q4 IMMUNOLOGY

AIDS research and human retroviruses Pub Date : 2025-08-04 DOI:10.1177/08892229251365946

Ana Flávia Novaes, Qesya Rodrigues Ferreira, Jéssica Oliveira de Souza Nascimento, Roberta Muniz Luz Silva, Matheus Nascimento Moura, Ariana Leal Borges da Cruz, Larissa Alves Fernandes, Arthur Shigueru Umeda, João Pedro de Melo de Freitas Santos, Aline Cristina Andrade Mota-Miranda, Davi Tanajura, Fernanda Khouri Barreto

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Abstract

The human T-lymphotropic virus 1 (HTLV-1) affects millions globally, notably in Brazil. The classical neurological presentation of this infection is HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is limited information on its association with lipid disorders and cardiovascular risks. Here, we compare the lipid profile of 30 people with HTLV-1 and HAM/TSP to 73 people with HTLV-1 without evidence of HAM/TSP from a Brazilian reference center between July 2021 and September 2023. People with HAM/TSP had lower levels of high-density lipoprotein and higher levels of low-density lipoprotein (LDL) and total cholesterol than people without HAM/TSP. In addition, people with HAM/TSP had a sixfold risk increase for elevated LDL. Therefore, patients with HAM/TSP show an adverse lipid profile, indicating higher dyslipidemia and cardiovascular risks. Regular lipid monitoring in this group is recommended.

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HAM/TSP患者的不良脂质特征和心血管风险增加

人类嗜t淋巴病毒1型（HTLV-1）影响全球数百万人，特别是在巴西。这种感染的典型神经学表现为htlv -1相关性脊髓病/热带痉挛性麻痹（HAM/TSP）。关于其与脂质紊乱和心血管风险的关联的信息有限。在这里，我们比较了来自巴西参考中心的30名HTLV-1和HAM/TSP患者与73名HTLV-1无HAM/TSP证据患者的脂质谱，时间为2021年7月至2023年9月。HAM/TSP患者的高密度脂蛋白水平较低，低密度脂蛋白（LDL）和总胆固醇水平高于非HAM/TSP患者。此外，患有HAM/TSP的人LDL升高的风险增加了六倍。因此，HAM/TSP患者表现出不利的血脂状况，表明血脂异常和心血管风险较高。建议这组患者定期进行血脂监测。

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来源期刊

AIDS research and human retroviruses 医学-病毒学

CiteScore

3.10

自引率

6.70%

发文量

201

审稿时长

3-6 weeks

期刊介绍： AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes. AIDS Research and Human Retroviruses coverage includes: HIV cure research HIV prevention science - Vaccine research - Systemic and Topical PreP Molecular and cell biology of HIV and SIV Developments in HIV pathogenesis and comorbidities Molecular biology, immunology, and epidemiology of HTLV Pharmacology of HIV therapy Social and behavioral science Rapid publication of emerging sequence information.