Surprising role of CMV in shaping outcomes of immunotherapy for melanoma — chronic infection yields favourable survival

IF 82.2 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2025-08-05 DOI:10.1038/s41571-025-01065-3

Anthony R. Cillo, John M. Kirkwood

引用次数: 0

Abstract

Recent clinical data indicate that infection with the common β-herpesvirus cytomegalovirus (CMV) confers beneficial effects on the T cell compartment that are associated with superior outcomes following immunotherapy in patients with melanoma. These findings warrant further studies of novel therapeutic strategies and biomarkers that might better predict clinical response to and toxicities of immunotherapy, based on systemic immune status.

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巨细胞病毒在形成黑色素瘤慢性感染免疫治疗结果中的惊人作用产生有利的生存

最近的临床数据表明，感染常见的β-疱疹病毒巨细胞病毒（CMV）对T细胞室有有益的影响，这与黑色素瘤患者免疫治疗后的良好预后有关。这些发现为进一步研究新的治疗策略和生物标志物提供了依据，这些新的治疗策略和生物标志物可能基于全身免疫状态更好地预测免疫治疗的临床反应和毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.