The impact of hypertensive disorders of pregnancy on maternal and perinatal outcomes in Ethiopia: an umbrella review of systematic reviews.

IF 2.4 Q2 OBSTETRICS & GYNECOLOGY

Frontiers in global women's health Pub Date : 2025-07-21 eCollection Date: 2025-01-01 DOI:10.3389/fgwh.2025.1571052

Teketel Ermias Geltore, Simegn Alemu, Tariku Laelago Ersado, Tamiru Beyene Uliso, Abebe Alemu Anshebo, Lakew Lafebo Foto

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Abstract

Background: Previous systematic reviews and meta-analyses have concentrated on the impacts of hypertensive disorders of pregnancy on maternal and perinatal outcomes in Ethiopia. Still, the evidence has often been inconsistent and inconclusive. Consequently, this study seeks to consolidate the findings regarding the effects of hypertensive disorders during pregnancy on maternal and perinatal outcomes in Ethiopia.

Methods: PubMed, Science Direct, Google Scholar, Africa Journal Online, PsycINFO, Research4Life, and CINAHL from September 15 to 25, 2024. The quality of the methods was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) tool. The estimates from the included studies were pooled and summarized using random-effects meta-analysis models.

Results: We included five systematic reviews and meta-analyses (SRM) studies with a total of 621,146 pregnant women. The pooled prevalence of hypertensive disorders of pregnancy was 16.56% (95% CI: 13.15-20.02), with a heterogeneity index (I² = 94.17%, P = 0.00). Maternal age >35 years, (AOR = 2.29; 95% CI: 2.05, 2.94), previous history of preeclampsia, (AOR = 3.51; 95% CI: 2.26, 5.53), low birth weight (AOR = 2.18; 95% CI: 1.48, 3.01), and alcohol consumption (AOR = 1.84; 95% CI: 1.12, 2.46) were the risk factors and complications of hypertensive disorders of pregnancy.

Conclusion: The higher rate of severe forms of HDP that are associated with significant maternal and perinatal complications is a major concern in Ethiopia. The risk of developing HDP is worse among women who have a history of preeclampsia, maternal age >35 years, alcohol consumption, and its complications, such as low birth weight.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024578548.

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妊娠高血压疾病对埃塞俄比亚孕产妇和围产期结局的影响：系统综述的总括性综述。

背景：以前的系统综述和荟萃分析集中在埃塞俄比亚妊娠高血压疾病对孕产妇和围产期结局的影响。尽管如此，证据往往是不一致和不确定的。因此，本研究旨在巩固有关妊娠期高血压疾病对埃塞俄比亚孕产妇和围产期结局的影响的研究结果。方法：PubMed、Science Direct、谷歌Scholar、Africa Journal Online、PsycINFO、Research4Life、CINAHL，时间为2024年9月15 - 25日。使用多系统评价（AMSTAR）工具评估方法的质量。采用随机效应荟萃分析模型对纳入研究的估计进行汇总和总结。结果：我们纳入了5项系统评价和荟萃分析（SRM）研究，共纳入621146名孕妇。妊娠期高血压疾病的总患病率为16.56% (95% CI: 13.15 ~ 20.02)，异质性指数（I2 = 94.17%, P = 0.00）。产妇年龄0 ~ 35岁，AOR = 2.29；95% CI: 2.05, 2.94)，既往子痫前期病史，(AOR = 3.51；95% CI: 2.26, 5.53)，低出生体重(AOR = 2.18；95% CI: 1.48, 3.01)和饮酒(AOR = 1.84；95% CI: 1.12, 2.46)为妊娠期高血压疾病的危险因素和并发症。结论：与显著的孕产妇和围产期并发症相关的严重形式HDP的较高发生率是埃塞俄比亚的一个主要问题。有先兆子痫病史、产妇年龄在50 ~ 35岁之间、饮酒及其并发症（如低出生体重）的妇女患HDP的风险更大。系统评审注册：https://www.crd.york.ac.uk/PROSPERO/view/CRD42024578548。

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