Netrin-1: Dual Roles in Neuroinflammation and Neurodegenerative Disease Dynamics.

IF 2 Q3 IMMUNOLOGY

International Journal of Inflammation Pub Date : 2025-07-28 eCollection Date: 2025-01-01 DOI:10.1155/ijin/8670048

Hadiseh Farahani, Ali Ganji, Ghasem Mosayebi, Mohsen Ebrahimi Monfared, Ali Ghazavi

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Abstract

Netrin-1, a central axonal guidance molecule discovered for its role in neuronal development, is also essential in neurodegenerative diseases. Netrin-1 inhibits leukocyte migration and inflammation-related tissue damage outside the central nervous system. Therefore, it can be viewed as a potential biomarker for inflammatory activity in neurodegenerative diseases. Recent studies highlight the dual roles of Netrin-1 in neuroinflammation and neurodegenerative diseases. In the context of neurodegeneration, Netrin-1 demonstrates both protective and harmful effects. This review highlights recent advancements in research regarding the dual roles of Netrin-1 in neuroinflammation and neurodegeneration. We discuss its involvement in protecting the blood-brain barrier (BBB) and regulating immune cell migration and its effects on various neurodegenerative diseases. A greater understanding of the multifunctionality of Netrin-1 could potentially be employed in developing new treatment modalities.

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Netrin-1：在神经炎症和神经退行性疾病动力学中的双重作用。

Netrin-1是一种中枢轴突引导分子，被发现在神经元发育中起作用，在神经退行性疾病中也很重要。Netrin-1抑制白细胞迁移和炎症相关的中枢神经系统外组织损伤。因此，它可以被视为神经退行性疾病中炎症活性的潜在生物标志物。最近的研究强调了Netrin-1在神经炎症和神经退行性疾病中的双重作用。在神经退行性疾病中，Netrin-1既具有保护作用，也具有有害作用。本文综述了近年来关于Netrin-1在神经炎症和神经变性中的双重作用的研究进展。我们讨论其参与保护血脑屏障（BBB）和调节免疫细胞迁移及其在各种神经退行性疾病中的作用。更深入地了解Netrin-1的多功能性可能有助于开发新的治疗方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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