Exploring the Genetic Landscape of Psoriatic Arthritis: A Narrative Review of Recent Genomic Studies.

Abstract

The recent availability of large-scale genomic datasets in psoriatic disease, combined with advances in molecular tools, next-generation genomic technologies, and informatics, has led to a better understanding of the genomic basis of psoriatic arthritis (PsA). While no current genetic tests exist for the management of PsA, the potential for early diagnosis and treatment orientation through genomic studies remains a source of continued optimism. Ongoing studies aim to advance the stratification, prognosis, and pharmacogenomics of PsA. This review highlights recent advances in the genomics of PsA, focusing on genomic variants that may become clinically actionable. We will discuss the importance of elucidating family history, highlight potential clinically significant psoriatic genes, emphasize genetic variants that may identify PsA among patients with psoriasis, and explore the emerging roles of transcript profiling, single-cell sequencing, and spatial omics in PsA.