Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube.

IF 6.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-07-31 DOI:10.1083/jcb.202507106

Tony J C Harris

引用次数: 0

Abstract

In this issue, Kim et al. (https://doi.org/10.1083/jcb.202409078) report that the scaffold protein Arc acts through Crumbs to spatially restrict where actomyosin-based apical constriction occurs across the invaginating Drosophila salivary gland. This restriction is needed for a long, thin tube to form.

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弧形扩散碎屑：组织内陷的空间限制，形成薄上皮管。

在这期杂志上，Kim等人（https://doi.org/10.1083/jcb.202409078）报道了支架蛋白Arc通过碎屑在空间上限制基于肌动球蛋白的尖端收缩发生在凹陷的果蝇唾液腺上。这种限制是长而细的管子形成所必需的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.