Cardiovascular implications of MASLD: overview of the evidence.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Scandinavian Journal of Gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI:10.1080/00365521.2025.2536585

Belend Ismail, Puria Nabilou, Lise Lotte Gluud, Søren Møller

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引用次数: 0

Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent and encompasses a spectrum from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), with potential progression to advanced fibrosis and cirrhosis.

Objective: This review provides an overview of the link between MASLD and cardiovascular disease.

Results: MASLD is closely linked to metabolic syndrome (MS) and cardiovascular disease, evidenced by increased coronary artery calcification, carotid intima-media thickness, epicardial adipose tissue, and pulse wave velocity, along with decreased flow-mediated dilation. These cardiovascular complications significantly heighten the risk of cardiovascular events and overall mortality.

Conclusion: MASLD seems to be an independent cardiovascular risk factor, but further studies are warranted to clarify the distinct impacts of MASLD stages and their interplay with MS on cardiovascular outcomes.

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MASLD对心血管的影响：证据综述。

背景：代谢功能障碍相关脂肪性肝病（MASLD）越来越普遍，包括从单纯脂肪变性到代谢功能障碍相关脂肪性肝炎（MASH），并有可能发展为晚期纤维化和肝硬化。目的：本文综述了MASLD与心血管疾病之间的联系。结果：MASLD与代谢综合征（MS）和心血管疾病密切相关，其证据包括冠状动脉钙化、颈动脉内膜-中膜厚度、心外膜脂肪组织和脉搏波速度增加，以及血流介导的扩张降低。这些心血管并发症显著增加心血管事件和总死亡率的风险。结论：MASLD似乎是一个独立的心血管危险因素，但需要进一步的研究来阐明MASLD分期的独特影响及其与MS对心血管结局的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

3.40

自引率

5.30%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The Scandinavian Journal of Gastroenterology is one of the most important journals for international medical research in gastroenterology and hepatology with international contributors, Editorial Board, and distribution