A narrative overview of Staphylococcus haemolyticus: resistance traits, virulence factors, and health impact.

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Reports Pub Date : 2025-07-27 DOI:10.1007/s11033-025-10773-z

U Meenatchi, A Sridevi, A E Harish Vikas, Piyush Jagdish Balgote, Jayanthi Sivaraman

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Abstract

Staphylococcus haemolyticus (S. haemolyticus) is a Gram-positive, facultative anaerobic bacterium emerging as a significant nosocomial pathogen, particularly in neonatal intensive care units. It primarily affects immunocompromised individuals and exhibits high levels of antibiotic resistance among coagulase-negative staphylococci (CoNS), underscores its global public health relevance. Advances in sequencing technologies have provided genomic insights into its pathogenicity, including biofilm formation and secretion of virulence factors. The organism is implicated in device-associated meningitis and neonatal central nervous system (CNS) infections. Current therapeutic challenges necessitate alternative treatment strategies, such as phage-derived endolysins and linezolid, especially when conventional options fail. This review outlines a comprehensive understanding of S. haemolyticus, focusing on its antibiotic resistance, virulence determinants, and the need for innovative approaches to combat healthcare-associated infections.

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溶血葡萄球菌的叙述概述：抗性性状，毒力因素，和健康影响。

溶血葡萄球菌（溶血葡萄球菌）是一种革兰氏阳性兼性厌氧细菌，是一种重要的医院病原体，特别是在新生儿重症监护病房。它主要影响免疫功能低下的个体，并在凝固酶阴性葡萄球菌（con）中表现出高水平的抗生素耐药性，强调了其全球公共卫生相关性。测序技术的进步提供了对其致病性的基因组学见解，包括生物膜的形成和毒力因子的分泌。该菌与器械相关的脑膜炎和新生儿中枢神经系统（CNS）感染有关。当前的治疗挑战需要替代治疗策略，如噬菌体衍生的内溶素和利奈唑胺，特别是当传统选择失败时。这篇综述概述了溶血链球菌的全面了解，重点是其抗生素耐药性，毒力决定因素，以及需要创新的方法来对抗卫生保健相关感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.