Diagnostic Performance of Mean Neutrophil Volume in Neonatal Sepsis.

IF 1.5 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-10-01 Epub Date: 2025-07-28 DOI:10.1007/s13312-025-00144-z

Santosh Kumar Panda, T Jenith, Nageswar Sahu, Palash Das, Sourav Padhee

引用次数: 0

Abstract

This study evaluated the diagnostic performance of mean neutrophil volume (MNV) in culture-positive neonatal sepsis. MNV (index test), measured using an automated hematology analyzer, was compared to blood culture (reference test) in a study including 535 neonates; 86 were culture-positive sepsis, 192 were probable sepsis, and 257 were not septic. The median (Q1, Q3) MNV (fL) was higher in culture-positive septic neonates compared to non-septic neonates [154 (152, 157) vs. 136 (133, 143), P = 0.001]. MNV > 151 fL diagnosed sepsis with 84.8% sensitivity, 89.4% specificity, 76% positive predictive value, and 94.7% negative predictive value with area under the receiver operating characteristic curve (AUROC) of 0.950 (95% CI 0.921, 0.971) suggesting it as a useful diagnostic tool for culture-positive neonatal sepsis.

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平均中性粒细胞体积在新生儿脓毒症中的诊断价值。

本研究评估了平均中性粒细胞体积（MNV）在培养阳性新生儿脓毒症中的诊断性能。在一项包括535名新生儿的研究中，使用自动血液学分析仪测量的MNV（指数测试）与血培养（参考测试）进行比较；脓毒症培养阳性86例，可能脓毒症192例，非脓毒症257例。脓毒症培养阳性新生儿的MNV （fL）中位数（Q1, Q3）高于非脓毒症新生儿[154（152,157）对136 (133,143),P = 0.001]。MNV > 151 fL诊断脓毒症的敏感性为84.8%，特异性为89.4%，阳性预测值为76%，阴性预测值为94.7%，受试者工作特征曲线下面积（AUROC）为0.950 (95% CI 0.921, 0.971)，提示其可作为培养阳性新生儿脓毒症的有效诊断工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.