New insights into lipid droplet breakdown in alcohol-associated hepatic steatosis.

IF 6.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-07-29 DOI:10.1083/jcb.202506103

Chen Zhang,Wen-Xing Ding

引用次数: 0

Abstract

The mechanisms by which alcohol increases lipid droplet accumulation are still unclear. In this issue, Sen et al. (https://doi.org/10.1083/jcb.202408205) identify a new pathway through which chronic alcohol exposure promotes hepatic steatosis via a UBXD8-p97/VCP-HSD17β13 axis, which regulates lipid droplet homeostasis.

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酒精相关性肝脂肪变性中脂滴分解的新见解

酒精增加脂滴积聚的机制尚不清楚。在这期杂志中，Sen等人（https://doi.org/10.1083/jcb.202408205）发现了慢性酒精暴露通过UBXD8-p97/VCP-HSD17β13轴促进肝脏脂肪变性的新途径，该轴调节脂滴稳态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.