Frontispiece: ortho-C─H Alkylation of Aryl Chlorides by a Catellani Strategy

Abstract

The Catellani reaction, a pivotal strategy for the construction of polysubstituted arenes, has seen the development of a series of aryl donor reagents. In this study (e202509300), Qianghui Zhou et al. demonstrate the difunctionalization of inert aryl chlorides via palladium/norbornene cooperative catalysis. The cover illustration symbolizes the breakthrough beyond traditional substrate limitations, enabling the Catellani reaction of aryl chlorides—a metaphorical representation of an airplane surpassing a train to signify scientific advancement.