Deep cortical layers are more vulnerable in Alzheimer's disease.

IF 15 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-07-23 DOI:10.1016/j.neuron.2025.06.022

S Zehra H Kazmi, Corette J Wierenga

引用次数: 0

Abstract

Network hyperexcitability is one of the hallmarks of the early stage of Alzheimer's disease (AD). In this issue of Neuron, Papanikolaou¹ and coworkers show that AD-mediated alterations start at the excitatory-inhibitory subcircuit in the deep layers of the cortex.

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大脑皮层深层更容易患阿尔茨海默病。

网络高兴奋性是阿尔茨海默病（AD）早期的标志之一。在这一期的《神经元》杂志上，Papanikolaou1及其同事表明，ad介导的改变始于皮层深层的兴奋抑制亚回路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.