Comprehensive Meta-Analysis on the Impact of the MDM2 SNP 309 T>G Gene Variant in Leukemia Susceptibility.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2025-07-23 DOI:10.2174/0113816128368759250527073556

Tarika Naik, Henu Kumar Verma, Madhubala Mulkalwar, Dinesh Mishra, Lvks Bhaskar

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引用次数: 0

Abstract

Introduction: Genetic factors play a significant role in the development of leukemia. The overexpression of MDM2 is associated with the progression of certain leukemias. This meta-analysis investigates the relationship between the MDM2 SNP 309T>G and various forms of leukemia across global populations.

Methods: A comprehensive literature search was conducted to retrieve genotyping data from twenty casecontrol studies related to MDM2 SNP 309T>G polymorphism and leukemia. A random-effects model was used to calculate the pooled odds ratio (OR) and 95% confidence interval (95% CI) for the association analysis. MetaGenyo software was utilized to conduct statistical analyses in this meta-analysis.

Results: The findings indicate a significant association between MDM2 309 SNPT>G polymorphism and leukemia in Asian and Caucasian populations. Additionally, this polymorphism is associated with an increased risk of Acute Myeloid Leukemia (AML) and Chronic Myeloid Leukemia (CML), implying that MDM2 may play a role in the pathogenesis of these specific forms of leukemia.

Conclusion: This meta-analysis suggests that MDM2 may represent a susceptibility gene for leukemia risk.

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MDM2 SNP 309t>g基因变异对白血病易感性影响的综合meta分析。

遗传因素在白血病的发生发展中起着重要作用。MDM2的过表达与某些白血病的进展有关。这项荟萃分析调查了MDM2 SNP 309T >g与全球人群中各种形式的白血病之间的关系。方法：对20项MDM2 SNP 309T>G多态性与白血病相关的病例对照研究进行综合文献检索，获取基因分型数据。采用随机效应模型计算关联分析的合并优势比（OR）和95%置信区间（95% CI）。meta分析采用MetaGenyo软件进行统计分析。结果：研究结果表明MDM2 309 SNPT>G多态性与亚洲和高加索人群白血病有显著相关性。此外，这种多态性与急性髓性白血病（AML）和慢性髓性白血病（CML）的风险增加有关，这意味着MDM2可能在这些特定形式的白血病的发病机制中发挥作用。结论：本荟萃分析提示MDM2可能是白血病风险的易感基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.