Comparison of the Prognostic Significance of Inflammatory and Thrombotic Indices in Patients with Cardiovascular and Infectious Diseases.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Israel Medical Association Journal Pub Date : 2025-07-01

Nir Roguin, Amir Cohen, Ella Yahud, Gabriel Bryk, Michal Cipok, Nadav Sorek, Eyal Ben-Assa, Eli I Lev

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引用次数: 0

Abstract

Background: Inflammatory and thrombotic markers play crucial roles in risk stratification for various diseases.

Objectives: To investigate the relative importance of inflammation, measured by C-reactive protein (CRP), and platelet turnover, indicated by immature platelet fraction (IPF), in predicting outcomes for patients with cardiovascular disease, coronavirus disease 2019 (COVID-19), and bacterial infections.

Methods: In this retrospective observational study, we analyzed data from 1473 individuals admitted to the Samson Assuta Ashdod University Hospital between 2018 and 2022. Patients were categorized based on CRP and IPF levels, with a focus on 280 patients in the high CRP/low IPF or high IPF/low CRP tertiles.

Results: The high CRP low IPF group demonstrated significantly higher mortality rates compared to the low CRP high IPF group (13.5% vs. 0.8%, P < 0.001). Logistic regression analysis revealed that the high CRP and low IPF combination was the strongest predictor of mortality (odds ratio 12.951, 95% confidence interval 1.409-119.020, P = 0.024).

Conclusions: The combination of inflammatory (CRP) and thrombotic (IPF) markers provides superior prognostic information compared to individual disease diagnoses in patients with cardiovascular disease, COVID-19, and bacterial infections.

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心血管和感染性疾病患者炎症和血栓指标对预后意义的比较

背景：炎症和血栓标志物在各种疾病的危险分层中起着至关重要的作用。目的：探讨炎症（以c反应蛋白（CRP）测量）和血小板周转率（以未成熟血小板分数（IPF）指示）在预测心血管疾病、冠状病毒病2019 （COVID-19）和细菌感染患者预后中的相对重要性。方法：在这项回顾性观察性研究中，我们分析了2018年至2022年在Samson Assuta Ashdod大学医院住院的1473名患者的数据。根据CRP和IPF水平对患者进行分类，重点关注280名高CRP/低IPF或高IPF/低CRP的患者。结果：高CRP -低IPF组的死亡率明显高于低CRP -高IPF组（13.5% vs. 0.8%, P < 0.001）。Logistic回归分析显示，高CRP和低IPF组合是死亡率的最强预测因子（优势比12.951,95%可信区间1.409 ~ 119.020,P = 0.024）。结论：与心血管疾病、COVID-19和细菌感染患者的单独疾病诊断相比，炎症（CRP）和血栓形成（IPF）标志物联合检测提供了更好的预后信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Israel Medical Association Journal 医学-医学：内科

CiteScore

2.20

自引率

12.50%

发文量

审稿时长

3-8 weeks

期刊介绍： The Israel Medical Association Journal (IMAJ), representing medical sciences and medicine in Israel, is published in English by the Israel Medical Association. The Israel Medical Association Journal (IMAJ) was initiated in 1999.