Long-term survival outcome after surgical resection of pulmonary neuroendocrine tumors.

IF 1.6 4区 医学 Q2 SURGERY
Eisuke Goto, Keiju Aokage, Kotaro Nomura, Makoto Tada, Yutaro Koike, Tetsuro Taki, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Kenji Suzuki, Genichiro Ishii, Masahiro Tsuboi
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引用次数: 0

Abstract

Purpose: Surgery is the standard treatment for early-stage pulmonary neuroendocrine tumors (NETs); however, long-term prognostic data are limited. This study aimed to establish the long-term outcomes of surgically resected pulmonary NETs.

Methods: This study included 263 patients who underwent pulmonary resection between January, 1997 and December, 2019: 89 with small cell lung carcinoma (SCLC), 120 with large cell neuroendocrine carcinoma (LCNEC), 14 with atypical carcinoid (AC), and 40 with typical carcinoid (TC). We analyzed clinicopathological characteristics and long-term prognosis.

Results: The 5-year relapse-free survival (RFS) rates were 38.7%, 54.2%, 62.3%, and 85.0%, and the 10-year RFS rates were 24.5%, 39.8%, 20.8%, and 76.4% for SCLC, LCNEC, AC, and TC, respectively. All deaths from TC occurred more than 5 years after surgery, whereas three of the four deaths from AC occurred after this period. Most patients with high-grade NETs had relapses within 3 years after surgery, whereas patients with AC had relapses not only in the early phase but also in the late phase.

Conclusions: The long-term prognosis of AC is comparable to that of high-grade NETs, suggesting that its biological characteristics might be more closely related to high-grade NETs than to TC.

肺神经内分泌肿瘤手术切除后的长期生存预后。
目的:手术是早期肺神经内分泌肿瘤(NETs)的标准治疗方法;然而,长期预后数据有限。本研究旨在确定手术切除肺网的长期预后。方法:本研究纳入了1997年1月至2019年12月期间接受肺切除术的263例患者:小细胞肺癌(SCLC) 89例,大细胞神经内分泌癌(LCNEC) 120例,非典型类癌(AC) 14例,典型类癌(TC) 40例。我们分析了临床病理特征和远期预后。结果:SCLC、LCNEC、AC和TC的5年无复发生存率(RFS)分别为38.7%、54.2%、62.3%和85.0%,10年RFS分别为24.5%、39.8%、20.8%和76.4%。所有TC死亡都发生在手术后5年以上,而4例AC死亡中有3例发生在这一时期之后。大多数高级别NETs患者在术后3年内复发,而AC患者不仅在早期复发,而且在晚期复发。结论:AC的远期预后与高级别NETs相当,提示其生物学特性与高级别NETs的关系可能比与TC的关系更密切。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Surgery Today
Surgery Today 医学-外科
CiteScore
4.90
自引率
4.00%
发文量
208
审稿时长
1 months
期刊介绍: Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.
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