Natural Products in Regulating Mitophagy for the Intervention of Atherosclerosis and Its Risk Factors: Mechanisms and Therapeutic Potential.

IF 6.1 2区医学 Q1 CHEMISTRY, MEDICINAL

Phytotherapy Research Pub Date : 2025-07-22 DOI:10.1002/ptr.70041

Yu-Han Li, Hao Ma, Ying-Rui Wang, Si-Xiang Zhang, You-Min Zhao, Zheng Liu

{"title":"Natural Products in Regulating Mitophagy for the Intervention of Atherosclerosis and Its Risk Factors: Mechanisms and Therapeutic Potential.","authors":"Yu-Han Li, Hao Ma, Ying-Rui Wang, Si-Xiang Zhang, You-Min Zhao, Zheng Liu","doi":"10.1002/ptr.70041","DOIUrl":null,"url":null,"abstract":"<p><p>Atherosclerosis (AS) is a chronic systemic disease that poses a significant and escalating global challenge. The pathological process of AS involves multiple aspects. In addition to lipid-lowering therapy, therapeutic strategies such as anti-inflammatory and immunotherapy have been proposed, and attention has been paid to the intervention of its risk factors. However, the available drugs are still limited. Therefore, there is an urgent need to discover new pharmacological targets and drugs. Mitophagy is closely associated with AS and its risk factors, and it represents an important breakthrough in the intervention of AS and its risk factors. Natural products (NPs), with multiple pharmacological activities and lower toxicity, have caught attention as the new force in the treatment of AS and its risk factors. This review discusses the mechanisms and therapeutic potential of NPs in regulating mitophagy to alleviate AS and intervene in its risk factors. It also introduces the application prospects of the NPs, with the expectation of contributing to the treatment of AS and the development of innovative drugs.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.1000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytotherapy Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ptr.70041","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Atherosclerosis (AS) is a chronic systemic disease that poses a significant and escalating global challenge. The pathological process of AS involves multiple aspects. In addition to lipid-lowering therapy, therapeutic strategies such as anti-inflammatory and immunotherapy have been proposed, and attention has been paid to the intervention of its risk factors. However, the available drugs are still limited. Therefore, there is an urgent need to discover new pharmacological targets and drugs. Mitophagy is closely associated with AS and its risk factors, and it represents an important breakthrough in the intervention of AS and its risk factors. Natural products (NPs), with multiple pharmacological activities and lower toxicity, have caught attention as the new force in the treatment of AS and its risk factors. This review discusses the mechanisms and therapeutic potential of NPs in regulating mitophagy to alleviate AS and intervene in its risk factors. It also introduces the application prospects of the NPs, with the expectation of contributing to the treatment of AS and the development of innovative drugs.

查看原文本刊更多论文

调节线粒体自噬干预动脉粥样硬化及其危险因素的天然产物：机制和治疗潜力。

动脉粥样硬化（AS）是一种慢性全身性疾病，对全球构成了重大且不断升级的挑战。AS的病理过程涉及多个方面。除降脂治疗外，还提出了抗炎、免疫治疗等治疗策略，并重视对其危险因素的干预。然而，可用的药物仍然有限。因此，迫切需要发现新的药理靶点和药物。线粒体自噬与AS及其危险因素密切相关，是AS及其危险因素干预研究的重要突破。天然产物（Natural products, NPs）具有多种药理活性和较低的毒性，已成为治疗as及其危险因素的新力量。本文就NPs在调节线粒体自噬以减轻AS和干预其危险因素方面的作用机制和治疗潜力作一综述。介绍了NPs的应用前景，期望为AS的治疗和创新药物的开发做出贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Phytotherapy Research 医学-药学

CiteScore

12.80

自引率

5.60%

发文量

325

审稿时长

2.6 months

期刊介绍： Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.