Recent advances in the three-component synthesis of difluorinated compounds.

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-07-23 DOI:10.1039/d5ob01027f

Zhan-Yong Wang, Ziyan Zhang, Weiyi Chen, Yang Liu, Aili Sun, Ran Xia

引用次数: 0

Abstract

The three-component reaction offers a convenient method for synthesizing difluorinated compounds. In this review, we classify and discuss synthetic methodologies developed over the past decade (2014-2024) into three categories: (a) radical reactions, (b) difluorocarbene-mediated fluorination, and (c) other reaction types, including those using nucleophilic and electrophilic fluorine reagents. Various reagents such as AgF, pyridine·9HF, Selectfluor II, TMSCF₃, TMSCF₂Br, TMSCF₂PO(OEt)₂, RCF₃, (CFCO)₂O, ClCF₂H, ClCF₂CO₂Na, CF₂HSO₂Na, [Ph₃PCF₂H]Br, ClCF₂Cl, BrCF₂R, ICF₂COAr, and BrCF₂CO₂Et will be discussed.

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三组分合成二氟化化合物的最新进展。

三组分反应为合成二氟化化合物提供了一种方便的方法。在这篇综述中，我们将过去十年（2014-2024）开发的合成方法分为三类：(a)自由基反应，(b)二氟化苯介导的氟化，以及(c)其他类型的反应，包括使用亲核和亲电氟试剂的反应。各种试剂如AgF、吡啶·9HF、selectfluii、TMSCF3、TMSCF2Br、TMSCF2PO(OEt)2、RCF3、（CFCO）2O、ClCF2H、ClCF2CO2Na、CF2HSO2Na、[Ph3PCF2H]Br、ClCF2Cl、BrCF2R、ICF2COAr和BrCF2CO2Et将被讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.