Radionuclide production for dose verification in VHEE FLASH radiotherapy

IF 1.5 3区物理与天体物理 Q3 INSTRUMENTS & INSTRUMENTATION

Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment Pub Date : 2025-07-17 DOI:10.1016/j.nima.2025.170832

Francesco Urso , Federica Baffigi , Esther Ciarrocchi , Leonida Antonio Gizzi , Petra Koester , Luca Labate , Matteo Morrocchi , Simona Piccinini , Martina Salvadori , Maria Giuseppina Bisogni

引用次数: 0

Abstract

This study explores the production of radionuclides in a PMMA (Polymethylmethacrylate) phantom irradiated with Very High Energy Electrons (VHEE) beams as a novel method for dose verification. In this work, Monte Carlo simulation studies using the Geant4 toolkit and experimental measurements with a VHEE beam produced by a laser-plasma accelerator were conducted. Specifically, the photonuclear production of ¹¹C, ¹⁵O and ¹³N is examined, with a detailed analysis of their spatial distribution, production yields and decay time.

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VHEE闪蒸放射治疗剂量验证的放射性核素生产

本研究探讨了PMMA（聚甲基丙烯酸甲酯）幻影在高能电子束照射下产生的放射性核素，作为一种新的剂量验证方法。在这项工作中，使用Geant4工具包进行了蒙特卡罗模拟研究，并对激光等离子体加速器产生的VHEE光束进行了实验测量。具体来说，研究了11C、15O和13N的光核产率，并详细分析了它们的空间分布、产率和衰变时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment 物理-光谱学

CiteScore

3.20

自引率

21.40%

发文量

787

审稿时长

1 months

期刊介绍： Section A of Nuclear Instruments and Methods in Physics Research publishes papers on design, manufacturing and performance of scientific instruments with an emphasis on large scale facilities. This includes the development of particle accelerators, ion sources, beam transport systems and target arrangements as well as the use of secondary phenomena such as synchrotron radiation and free electron lasers. It also includes all types of instrumentation for the detection and spectrometry of radiations from high energy processes and nuclear decays, as well as instrumentation for experiments at nuclear reactors. Specialized electronics for nuclear and other types of spectrometry as well as computerization of measurements and control systems in this area also find their place in the A section. Theoretical as well as experimental papers are accepted.