Front Cover: Design of Potent Mannose-6-Phosphate Derivatives as Ligands for CI-M6P/IGF2R Using Fluorescence Polarization Assay

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-07-23 DOI:10.1002/chem.202584001

Lucie Mrázková, Klaudia Hladoníková, Barbora Toncarová, Michal Fischer, Jakub Zýka, Jaroslav Kozák, Michal Kráľ, Milan Kožíšek, Jiří Jiráček, Jakub Kaminský, Kamil Parkan, Lenka Žáková

引用次数: 0

Abstract

High-affinity M6P mimetics. In their Research Article (DOI: 10.1002/chem.202500973), J. Kaminský, K. Parkan, L. Žáková and co-workers report how they designed stable mannose-6-phosphate derivatives and evaluated their binding to CI-M6P/IGF2R by using a fluorescence polarization assay. Multivalent ligands and phosphonate-based mimetics showed enhanced affinity, offering promising tools for targeted lysosomal delivery. Artwork by Tomáš Belloň / IOCB Prague.

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封面：利用荧光偏振法设计强效甘露糖-6-磷酸衍生物作为CI-M6P/IGF2R的配体

高亲和力M6P模仿者。在他们的研究文章（DOI: 10.1002/chem.202500973）中，J. Kaminský， K. Parkan， L. Žáková及其同事报告了他们如何设计稳定的甘露糖-6-磷酸衍生物，并使用荧光偏振法评估其与CI-M6P/IGF2R的结合。多价配体和基于膦酸盐的模拟物显示出增强的亲和力，为靶向溶酶体递送提供了有希望的工具。艺术作品：Tomáš bellokv /布拉格国际奥委会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.