Clinical significance of serum lipoprotein(a) in the early diagnosis of intrahepatic cholestasis of pregnancy

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-07-23 DOI:10.1111/jog.70002

Xiaohong Zhu, Yeliang Sun, Yongli Zhou, Liping Han, Yuqin Hu, Qin Li, Yuhua Wei

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Abstract

Objective

Intrahepatic cholestasis of pregnancy (ICP) represents the predominant hepatic condition that is specific to pregnancy and impacts expectant mothers. We desired to explore the clinical significance of serum lipoprotein(a) [Lp(a)] in the early diagnosis of ICP.

Methods

A retrospective study was conducted on 156 ICP patients, with 88 healthy pregnant women with normal indicators during mid-to-late pregnancy selected as controls. Clinical baseline data of all participants were collected, and serum Lp(a) expression was measured by turbidimetric immunoassay. The association between fasting serum total bile acids (TBA) and serum Lp(a) in ICP patients was evaluated using Spearman correlation analysis. The value of serum Lp(a) was assessed using ROC analysis in assessing high-risk ICP patients and diagnosing early-onset ICP.

Results

The ICP group had significantly higher weight gain during pregnancy, family history of ICP, histories of cholecystectomy and gallbladder disease, with higher fasting serum TBA. The gestational age in the ICP group was significantly shorter, with increased serum Lp(a) levels. Serum Lp(a) levels enhanced with disease severity and were positively correlated with fasting serum TBA. Early-onset ICP patients had higher serum Lp(a) levels than late-onset ICP patients.

Conclusion

Serum Lp(a) levels increased with disease severity in ICP patients, providing effective guidance for early diagnosis and clinical treatment decisions in ICP patients.

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血清脂蛋白(a)在妊娠肝内胆汁淤积症早期诊断中的临床意义

目的妊娠期肝内胆汁淤积症（ICP）是妊娠期主要的肝脏疾病，主要影响孕妇。我们希望探讨血清脂蛋白(a) [Lp(a)]在ICP早期诊断中的临床意义。方法对156例ICP患者进行回顾性研究，选取88例妊娠中后期各项指标正常的健康孕妇作为对照。收集所有参与者的临床基线数据，并通过浊度免疫分析法测定血清Lp(a)的表达。采用Spearman相关分析评价ICP患者空腹血清总胆汁酸（TBA）与血清Lp(a)的相关性。采用ROC分析评估血清Lp(a)在评估ICP高危患者和诊断早发性ICP中的价值。结果ICP组妊娠期体重增加、ICP家族史、胆囊切除术史、胆囊疾病史显著增高，空腹血清TBA增高。ICP组胎龄明显缩短，血清Lp(a)水平升高。血清Lp(a)水平随疾病严重程度升高而升高，并与空腹血清TBA呈正相关。早发性ICP患者血清Lp(a)水平高于晚发性ICP患者。结论血清Lp(a)水平随ICP患者病情加重而升高，可为ICP患者早期诊断和临床治疗决策提供有效指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.