Rapid, solvent- and catalyst-free transamidation of aliphatic amines with formamide

Abstract

A rapid and effective transamidation process using formamide as both solvent and reactant for the N-formylation of aliphatic amines has been developed. The method does not require the use of catalysts or column chromatography for purification, thereby simplifying the synthetic procedure. This innovative method is environmentally friendly and highly efficient, exhibits excellent reaction kinetics, demonstrates broad substrate adaptability and excellent functional group tolerance, and is also suitable for synthesizing or modifying certain amine-containing drug molecules.