Are Extracellular Vesicles Used in Tissue Engineering Effective for Regenerative Endodontic Treatments? Scoping Review.

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2025-07-18 DOI:10.1111/aej.12980

Carolina Dos Santos Santinoni, Jéssica Pestana, Lívia Apolito Rissi, Milena de Queiroz Guedes, Graziela Garrido Mori Panucci

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引用次数: 0

Abstract

The purpose was to analyse the efficacy of extracellular vesicles (EVs) used in tissue engineering for regenerative endodontic treatments. The study followed the Guidance's recommendations for conducting systematic scoping reviews. A systematic electronic search was conducted to answer: "Are extracellular vesicles used in tissue engineering effective for regenerative endodontic treatments?". A total of 393 scientific articles were selected, and after applying the inclusion criteria and excluding duplicate articles, 14 articles were included in this research. The most used EVs were exosomes, which were mostly extracted from stem cells and used in association with biomaterials or cells. All included studies demonstrated the effectiveness of extracellular vesicles in promoting pulp regeneration. The mechanisms involved in tissue formation include odontogenic and angiogenic differentiation, as well as control of the inflammatory process after the use of EVs. It is concluded that therapy with EVs is promising for endodontic clinics.

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组织工程中使用细胞外囊泡对再生牙髓治疗有效吗？确定审核范围。

目的是分析细胞外囊泡（EVs）在组织工程中用于再生牙髓治疗的效果。该研究遵循了指南关于进行系统范围审查的建议。系统的电子搜索是为了回答：“组织工程中使用的细胞外囊泡对再生牙髓治疗有效吗？”共选择393篇科学论文，应用纳入标准并剔除重复文章后，本研究共纳入14篇。使用最多的ev是外泌体，它们主要从干细胞中提取，并与生物材料或细胞结合使用。所有纳入的研究都证明了细胞外囊泡在促进牙髓再生方面的有效性。参与组织形成的机制包括牙源性和血管生成分化，以及使用ev后炎症过程的控制。结论：EVs治疗牙髓临床是有希望的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.