Sexual dysfunction and its impact on quality of life among female haematological cancer patients: a cross-sectional study in Malaysia.

IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Supportive Care in Cancer Pub Date : 2025-07-15 DOI:10.1007/s00520-025-09726-w

Gin-Gin Gan, Diana-Leh-Ching Ng, Jesinda Pauline Kerishnan, Chong-Guan Ng

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引用次数: 0

Abstract

Background: S exual dysfunction (SD) and quality of life (QoL) are significantly impacted by cancer and its treatments. However, information on sexual function is scarce, particularly among female patients with underlying haematological malignancies in Asia. This study is aimed at determining the prevalence of SD in these patients, identifying associated factors, and examining their effects on QoL.

Methods: This cross-sectional study, conducted in Malaysia from 2014 to 2016, involved female patients with haematological malignancies who were on active treatment or had completed active treatment. Sociodemographic and clinical data were obtained through patient interviews and medical records. Sexual functions were assessed using the Female Sexual Function Index, psychological aspects with the Hospital Anxiety and Depression Scale (HADS), and health-related QoL using the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 version 3.0 questionnaire. Data were analysed using SPSS software.

Results: Of the 89 patients recruited, 82% reported SD. Significant associations were found between SD and menopause (OR, 5.7; 95% CI, 1.60-20.34; p = 0.007) and higher HADS-depression score (OR, 1.6; 95% CI, 1.14-2.21; p = 0.006). Patients with SD exhibited lower median scores in Global Health Status/QoL (QL2) (66.7 [IQR 33.3] vs. 91.7 [IQR 33.3], p = 0.009), role function (83.3 [IQR 33.3] vs. 100 [IQR 16.7], p = 0.033), cognitive function (83.3 [IQR 25.0] vs. 100 [IQR 16.7]), and pain (33.3 [IQR 33.3] vs. 0 [IQR 16.7]). Weak positive correlations were observed between FSFI score and QL2 (Rs = 0.252, p = 0.018) and cognitive function (Rs = 0.237, p = 0.026), while a moderate positive correlation was found with role function (Rs = 0.315, p = 0.003).

Conclusions: SD is highly prevalent in female patients with haematological cancers, significantly impacting QoL, and this needs to be addressed accordingly.

查看原文本刊更多论文

性功能障碍及其对女性血液病癌症患者生活质量的影响：马来西亚的一项横断面研究

背景：癌症及其治疗对性功能障碍（SD）和生活质量（QoL）有显著影响。然而，关于性功能的信息很少，特别是在亚洲有潜在血液恶性肿瘤的女性患者中。本研究旨在确定这些患者中SD的患病率，确定相关因素，并检查其对生活质量的影响。方法：这项横断面研究于2014年至2016年在马来西亚进行，涉及正在积极治疗或已完成积极治疗的女性血液系统恶性肿瘤患者。通过病人访谈和医疗记录获得社会人口学和临床数据。性功能评估采用女性性功能指数，心理方面采用医院焦虑和抑郁量表（HADS），健康相关生活质量评估采用欧洲癌症研究和治疗组织生活质量调查问卷Core 30 3.0版。数据采用SPSS软件进行分析。结果：89例患者中，82%报告SD。SD与绝经期之间存在显著相关性(OR, 5.7；95% ci, 1.60-20.34；p = 0.007)和较高的hads -抑郁评分(OR, 1.6；95% ci, 1.14-2.21；p = 0.006)。SD患者在全球健康状况/生活质量（QL2）（66.7 [IQR 33.3]比91.7 [IQR 33.3], p = 0.009）、角色功能（83.3 [IQR 33.3]比100 [IQR 16.7], p = 0.033）、认知功能（83.3 [IQR 25.0]比100 [IQR 16.7]）和疼痛（33.3 [IQR 33.3]比0 [IQR 16.7]）中位数得分较低。FSFI评分与QL2评分（Rs = 0.252, p = 0.018）、认知功能评分（Rs = 0.237, p = 0.026）呈弱正相关，与角色功能评分（Rs = 0.315, p = 0.003）呈中度正相关。结论：SD在女性血液学癌症患者中高发，显著影响生活质量，需要相应解决。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.