Novel Heterocyclic 5H‑Dibenzo[b,f]azepine Derivatives as Selective HDAC6 Inhibitors for Treatment of Charcot Marie Tooth Disease.

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-06-18 eCollection Date: 2025-07-10 DOI:10.1021/acsmedchemlett.5c00344

Steven H Liang

引用次数: 0

Abstract

This highlight describes novel substituted 5H-dibenzo-[b,f]-azepine compounds and their diverse biological applications. These compounds serve as selective inhibitors of histone deacetylase 6 (HDAC6), and provide methods for the treatment of a broad scope of indications, including Charcot Marie Tooth Disease (CMT).

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新型杂环5H -二苯并[b，f]氮平衍生物作为选择性HDAC6抑制剂治疗夏可氏乳牙病。

本重点介绍了新的取代5h -二苯并-[b，f]-氮平类化合物及其不同的生物应用。这些化合物作为组蛋白去乙酰化酶6 （HDAC6）的选择性抑制剂，并提供了治疗广泛适应症的方法，包括夏可玛丽牙病（CMT）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.