Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL.

IF 3 3区物理与天体物理

Journal of Synchrotron Radiation Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI:10.1107/S1600577525005016

Meitian Wang

引用次数: 0

Abstract

This review highlights the development and evolution of three macromolecular crystallography (MX) beamlines at the Swiss Light Source (SLS) over the past two decades. We discuss key advancements in X-ray optics, detectors, goniometers, sample changers and MX methodology, emphasizing their impact on high-throughput and high-resolution structural biology. Our contributions are presented within the broader context of global efforts in synchrotron-based MX. Looking ahead, we explore the future experiments enabled by SLS 2.0 and new opportunities at SwissFEL to enhance experimental capabilities and drive scientific discoveries.

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瑞士光源和瑞士自由电子激光器下大分子晶体学光束线的演变。

本文综述了近二十年来瑞士光源（SLS）下三种大分子晶体学（MX）光束线的发展和演变。我们讨论了x射线光学、探测器、测角仪、样品交换器和MX方法的关键进展，强调了它们对高通量和高分辨率结构生物学的影响。我们的贡献是在基于同步加速器的MX的全球努力的更广泛背景下提出的。展望未来，我们将探索SLS 2.0支持的未来实验以及瑞士自由电子实验室的新机遇，以提高实验能力并推动科学发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Synchrotron Radiation INSTRUMENTS & INSTRUMENTATIONOPTICS&-OPTICS

CiteScore

5.60

自引率

12.00%

发文量

289

审稿时长

1 months

期刊介绍： Synchrotron radiation research is rapidly expanding with many new sources of radiation being created globally. Synchrotron radiation plays a leading role in pure science and in emerging technologies. The Journal of Synchrotron Radiation provides comprehensive coverage of the entire field of synchrotron radiation and free-electron laser research including instrumentation, theory, computing and scientific applications in areas such as biology, nanoscience and materials science. Rapid publication ensures an up-to-date information resource for scientists and engineers in the field.