The Combination of Natural Products: A Promising Therapeutical Way for Management of Breast Cancers.

IF 6.3 2区医学 Q1 CHEMISTRY, MEDICINAL

Phytotherapy Research Pub Date : 2025-09-01 Epub Date: 2025-07-14 DOI:10.1002/ptr.70044

Pei-Pei Wang, Cheng-Xun He, Yang-Yang Shuai, Hai-Jun Zhang, Lei Zhang, Hui Ao, Wei Peng, Hong Zhang

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引用次数: 0

Abstract

Breast cancer currently exhibits the highest incidence rate among gynecological malignancies worldwide. Natural products, which have been extensively utilized in antiviral therapies globally, demonstrate unique therapeutic advantages in breast cancer management through combinatorial applications. This article reviews recent advances in both the therapeutic effectiveness and underlying mechanisms of natural product combination therapy for breast cancer. These combinations simultaneously target multiple oncogenic pathways by inhibiting cellular proliferation and viability, suppressing autophagy and angiogenesis, blocking invasion and metastasis, and inducing cell cycle arrest and apoptosis. Beyond their direct anticancer effects, natural product combinations modulate immune responses and remodel the tumor microenvironment, offering novel therapeutic perspectives. However, rigorously designed clinical trials remain essential to validate the clinical efficacy of natural product-chemotherapeutic combinations in breast cancer treatment.

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天然产物的结合：一种有前途的治疗乳腺癌的方法。

乳腺癌是目前世界范围内发病率最高的妇科恶性肿瘤。天然产物已广泛应用于全球抗病毒治疗中，通过组合应用在乳腺癌治疗中显示出独特的治疗优势。本文综述了天然产物联合治疗乳腺癌的疗效和潜在机制的最新进展。这些组合通过抑制细胞增殖和活力，抑制自噬和血管生成，阻断侵袭和转移，诱导细胞周期阻滞和凋亡，同时靶向多种致癌途径。除了它们的直接抗癌作用，天然产物组合调节免疫反应和重塑肿瘤微环境，提供了新的治疗前景。然而，严格设计的临床试验对于验证天然产物-化疗联合治疗乳腺癌的临床疗效仍然至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytotherapy Research 医学-药学

CiteScore

12.80

自引率

5.60%

发文量

325

审稿时长

2.6 months

期刊介绍： Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.