Network pharmacology research and experimental verification of dietary flavonoid fisetin in treating myocardial hypertrophy.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-14 DOI:10.1080/10286020.2025.2526826

Hui Chen, Li-Li Jiang, Chun-Mei Luo, Tian-Yu Chen, Chang-Han Ouyang

引用次数: 0

Abstract

In this study, network pharmacology was developed to study the mechanism of fisetin in the treatment of myocardial hypertrophy. A total of 41 common targets were obtained through multi-database screening, and the core targets were determined by PPI network analysis. KEGG enrichment suggested that the effects of fisetin were mainly related to PI3K-AKT and apoptotic pathways. Western blot experiments confirmed that fisetin inhibited endoplasmic reticulum stress and apoptosis by regulating the expression of PI3K, AKT, GRP78, CHOP and Bax proteins. Our results provide promising guidance for the subsequent clinical application of fisetin in the treatment of myocardial hypertrophy.

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膳食黄酮类非瑟酮治疗心肌肥厚的网络药理学研究及实验验证。

本研究采用网络药理学的方法研究非西汀治疗心肌肥厚的作用机制。通过多数据库筛选共获得41个常见靶点，通过PPI网络分析确定核心靶点。KEGG富集提示非瑟酮的作用主要与PI3K-AKT和凋亡通路有关。Western blot实验证实，非西汀通过调节PI3K、AKT、GRP78、CHOP和Bax蛋白的表达抑制内质网应激和凋亡。本研究结果为非西汀治疗心肌肥厚的后续临床应用提供了良好的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.