{"title":"The Golgi Apparatus as a Strategic Target in Cancer: Mechanisms, Diagnosis and Therapeutic Opportunities.","authors":"Chao Cui, Chenglu Sun, Peng Yuan, Shibo Tian, Hailong Xie, Funeng Xu, Haohuan Li","doi":"10.1080/1061186X.2025.2527867","DOIUrl":null,"url":null,"abstract":"<p><p>The Golgi apparatus, a central hub for protein processing and transportation, plays a critical role in cancer progression and has thus emerged as a highly promising therapeutic target. This review discusses the molecular mechanisms underlying Golgi dysfunction in cancer, along with recent advancements in Golgi imaging techniques that enable precise visualization of structural and functional alterations within tumors. Furthermore, we highlighted representative applications of Golgi-targeting strategies in cancer diagnosis and treatment, and also discussed future directions for Golgi-targeted therapies, emphasizing the potential of the Golgi apparatus as a multidimensional target for cancer management. This study will provide valuable insights for research related to cancer therapeutics.</p>","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-32"},"PeriodicalIF":3.9000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Targeting","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1061186X.2025.2527867","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
The Golgi apparatus, a central hub for protein processing and transportation, plays a critical role in cancer progression and has thus emerged as a highly promising therapeutic target. This review discusses the molecular mechanisms underlying Golgi dysfunction in cancer, along with recent advancements in Golgi imaging techniques that enable precise visualization of structural and functional alterations within tumors. Furthermore, we highlighted representative applications of Golgi-targeting strategies in cancer diagnosis and treatment, and also discussed future directions for Golgi-targeted therapies, emphasizing the potential of the Golgi apparatus as a multidimensional target for cancer management. This study will provide valuable insights for research related to cancer therapeutics.
期刊介绍：
Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs.
Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.
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