Low hand grip strength is associated with increased risk of cognitive impairment in older men, including men with probable sarcopenic obesity: results from the Northern Ireland PRIME-COG cohort.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2025-07-11 DOI:10.1159/000547314

Dominic N Farsi, Gareth J McKay, Gerry J Linden, Michael McAlinden, Jessica Teeling, Peter Passmore, Clive Holmes, Christopher C Patterson, Bernadette McGuinness, Claire T McEvoy

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引用次数: 0

Abstract

Background: The relationship between cognitive impairment and a phenotype comprising low muscle strength coupled with excess adiposity, representative of sarcopenic obesity, is not well defined. The present study aimed to elucidate the relationship between low hand grip strength (HGS), representative of 'probable sarcopenia', coupled with obesity, thus representing 'probable sarcopenic obesity', and cognitive impairment.

Methods: Logistic regression models were implemented between probable sarcopenia and cognitive impairment in older men residing in Northern Ireland within the PRIME-COG cohort, a nested study in the PRIME (Prospective Epidemiological Study of Myocardial Infarction) cohort. In addition, associations across Body Mass Index (BMI) strata were evaluated, including probable sarcopenic obesity (low HGS and BMI ≥ 30 kg/m2). Models were adjusted for demographics, cardiometabolic disease and risk factors, APOE-ε4, and lifestyle behaviours.

Results: Among 792 men (79.1 SD 3.2 yr), low HGS was associated with a significantly increased odds ratio (OR) of cognitive impairment (OR 2.14 (95% confidence intervals (CI) 1.51 - 3.03), p < 0.001). The risk was broadly consistent across BMI strata, including men with probable sarcopenic obesity (OR 2.36 (95% CI 0.85 - 6.35), p = 0.05). The consistent risk across BMI strata was supported by a non-significant interaction between BMI and probable sarcopenia (likelihood ratio test, p = 0.772).

Conclusions: Probable sarcopenia, indicated by low HGS, was associated with an increased risk of cognitive impairment in older men, with risk consistent across BMI strata, including men living with probable sarcopenic obesity. Our findings have clinical relevance, suggesting that phenotypes comprising low muscle strength, in the presence of excess adiposity must not be overlooked and appropriate interventions explored to attenuate physical perturbations which could carry significance towards ameliorating cognitive function in aging.

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来自北爱尔兰PRIME-COG队列研究的结果表明，握力低与老年男性认知障碍风险增加有关，包括可能患有肌肉减少性肥胖的男性。

背景：认知障碍与低肌力伴过度肥胖的表型之间的关系尚不明确，而低肌力伴过度肥胖是肌少性肥胖的代表。本研究旨在阐明低握力（HGS）与肥胖之间的关系，HGS代表“可能的肌肉减少症”，因此代表“可能的肌肉减少性肥胖”，以及认知障碍。方法：在PRIME- cog队列（PRIME（前瞻性心肌梗死流行病学研究）队列的嵌套研究）中，对居住在北爱尔兰的老年男性进行可能的肌肉减少症和认知障碍之间的Logistic回归模型。此外，还评估了身体质量指数（BMI）各阶层之间的关联，包括可能的肌肉减少型肥胖（低HGS和BMI≥30 kg/m2）。根据人口统计学、心脏代谢疾病和危险因素、APOE-ε4和生活方式行为对模型进行了调整。结果：在792名男性（79.1 SD 3.2年）中，低HGS与认知功能障碍的优势比（OR）显著增加相关（OR 2.14(95%可信区间（CI） 1.51 - 3.03), p < 0.001）。该风险在BMI各阶层中大致一致，包括可能患有肌肉减少性肥胖的男性（OR 2.36 (95% CI 0.85 - 6.35), p = 0.05）。BMI和可能的肌肉减少症之间不存在显著的相互作用（似然比检验，p = 0.772），支持了BMI各阶层之间一致的风险。结论：低HGS表明的可能的肌肉减少症与老年男性认知功能障碍的风险增加有关，其风险在BMI各阶层中是一致的，包括可能患有肌肉减少性肥胖的男性。我们的研究结果具有临床相关性，表明在存在过度肥胖的情况下，不应忽视包括低肌肉力量的表型，并探索适当的干预措施来减轻身体扰动，这可能对改善衰老过程中的认知功能具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.