The sick gut with diarrhea: FODMAPS for treatment?

IF 3.5 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2025-09-01 Epub Date: 2025-07-07 DOI:10.1097/MCO.0000000000001141

Pascal Crenn

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引用次数: 0

Abstract

Purpose of review: To examine in the light of recent data whether diets low in FODMAPs (a now classic exclusion diet for treatment for IBS: irritable bowel syndrome) have shown interest/efficacy in diseases of the digestive tract (beyond IBS) manifesting as diarrhea.

Recent findings: Very little good quality data or publications are available in recent medical literature. It is therefore difficult to estimate that the low FODMAP diet can be considered with a good level of confidence outside of IBS except in borderline symptomatic forms or with associated pathophysiology (e.g. IBD: inflammatory bowel disease).

Summary: There is a lack of quality data on the benefits, safety and value of LFD, outside of IBS. This is particularly the case in the majority of organic digestive diseases, notably with diarrhea, unless accompanied by dysregulation of the intestine-brain axis (and so with IBS symptoms), for example in post-inflammatory situations. When effective, which is currently highly unpredictable, the mechanism of action remains poorly understood.

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腹泻的肠道疾病：FODMAPS治疗？

综述的目的：根据最近的数据，检查低FODMAPs饮食（现在是治疗肠易激综合征的经典排除饮食）是否对消化道疾病（除肠易激综合征外）表现为腹泻有兴趣/疗效。最近的发现：在最近的医学文献中，很少有高质量的数据或出版物。因此，除了边缘症状形式或伴有相关病理生理（如IBD：炎症性肠病）外，很难估计低FODMAP饮食是否可以在肠易激综合征之外被认为是可靠的。总结：在IBS之外，缺乏关于LFD的益处、安全性和价值的高质量数据。在大多数器质性消化系统疾病中尤其如此，特别是腹泻，除非伴有肠脑轴失调（因此伴有肠易激综合征），例如在炎症后情况下。当有效时（目前是高度不可预测的），其作用机制仍然知之甚少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Clinical Nutrition and Metabolic Care 医学-内分泌学与代谢

CiteScore

5.30

自引率

6.50%

发文量

116

审稿时长

6-12 weeks

期刊介绍： A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.