{"title":"iCAFs control chemoresistance","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01068-w","DOIUrl":null,"url":null,"abstract":"<p>Distinct populations of cancer-associated fibroblasts (CAFs) that influence therapy response have been discovered in bladder cancer. Inflammatory CAFs (iCAFs) support the expansion of cancer stem cells, driving chemoresistance and providing potential therapeutic targets.</p><p>Analysis of matched prechemotherapy and postchemotherapy tumour samples from patients with chemoresistant bladder cancer revealed a significantly enriched fibroblast gene signature in postchemotherapy samples (<i>P</i> < 0.0001). Specifically, notable upregulation of <i>COL3A1</i>, <i>IL6</i> and <i>PDGFRB</i> was observed. However, no increase in the classical myofibroblastic CAF (myCAF) marker <i>ACTA2</i> was found. Multiplex immunohistochemistry costaining for αSMA with PDGFRβ, collagen III and IL-6 in human bladder cancer tissue sections showed the existence of two CAF subpopulations: αSMA<sup>+</sup>PDGFRβ<sup>+</sup> and αSMA<sup>−</sup>PDGFRβ<sup>+</sup>. Most CAFs in both subpopulations also expressed IL-6.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"23 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-025-01068-w","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Distinct populations of cancer-associated fibroblasts (CAFs) that influence therapy response have been discovered in bladder cancer. Inflammatory CAFs (iCAFs) support the expansion of cancer stem cells, driving chemoresistance and providing potential therapeutic targets.
Analysis of matched prechemotherapy and postchemotherapy tumour samples from patients with chemoresistant bladder cancer revealed a significantly enriched fibroblast gene signature in postchemotherapy samples (P < 0.0001). Specifically, notable upregulation of COL3A1, IL6 and PDGFRB was observed. However, no increase in the classical myofibroblastic CAF (myCAF) marker ACTA2 was found. Multiplex immunohistochemistry costaining for αSMA with PDGFRβ, collagen III and IL-6 in human bladder cancer tissue sections showed the existence of two CAF subpopulations: αSMA+PDGFRβ+ and αSMA−PDGFRβ+. Most CAFs in both subpopulations also expressed IL-6.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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