{"title":"Peripheral chromatin remodeling at the center of zygotic genome activation.","authors":"Laure de Chancel, Jean-Léon Maître","doi":"10.1016/j.xgen.2025.100922","DOIUrl":null,"url":null,"abstract":"<p><p>Pal and colleagues<sup>1</sup> investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable during the very early steps of mouse development when they can be rescued at the 2-cell stage.</p>","PeriodicalId":72539,"journal":{"name":"Cell genomics","volume":"5 7","pages":"100922"},"PeriodicalIF":11.1000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278610/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell genomics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.xgen.2025.100922","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pal and colleagues1 investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable during the very early steps of mouse development when they can be rescued at the 2-cell stage.
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