Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review.

IF 5.8 1区医学 Q1 PSYCHIATRY

Translational Psychiatry Pub Date : 2025-07-10 DOI:10.1038/s41398-025-03423-2

Yiling Guo, Nanfang Pan, Yuhan Zou, Yajing Long, Xun Zhang, Qingyuan Li, Xueling Suo, Manpreet K Singh, Song Wang, Qiyong Gong

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引用次数: 0

Abstract

The COVID-19 pandemic has posed an unprecedented threat to global health. However, neural substrates underlying mental health vulnerabilities brought by the pandemic remain elusive. We conducted a systematic review relating structural and functional brain abnormalities to mental health issues associated with COVID-19 at brain regional and network levels. A literature search on neuroimaging studies of mental health problems derived by COVID-19 was conducted in the PubMed, Web of Science and MEDLINE databases. We identified 46 studies across various imaging techniques and found that COVID-19-related mental health problems were principally associated with brain structural and functional alterations in the prefrontal cortex, insula, cingulate, hippocampus, and amygdala, as well as the affective cortical network. This review may facilitate the targeted development of therapies tailored to the pandemic context and provide insights for proactive prevention against future collective stressors and traumas.

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神经影像学对COVID-19大流行的社会心理影响的洞察：一项系统综述。

新冠肺炎大流行给全球健康带来了前所未有的威胁。然而，大流行带来的心理健康脆弱性背后的神经基础仍然难以捉摸。我们在大脑区域和网络水平上对与COVID-19相关的心理健康问题的结构和功能脑异常进行了系统综述。在PubMed、Web of Science和MEDLINE数据库中检索有关COVID-19衍生精神健康问题的神经影像学研究的文献。我们通过各种成像技术确定了46项研究，发现与covid -19相关的心理健康问题主要与前额叶皮层、脑岛、扣带回、海马体和杏仁核以及情感皮层网络的大脑结构和功能改变有关。这一综述可能有助于针对大流行背景有针对性地开发治疗方法，并为主动预防未来的集体压力源和创伤提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Psychiatry PSYCHIATRY-

CiteScore

11.50

自引率

2.90%

发文量

484

审稿时长

23 weeks

期刊介绍： Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.